Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice. - Wikidata - wikimedia - TriplyDB

Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice.

Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice.

http://www.wikidata.org/entity/Q43696734

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Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice Oxidized cholesterol as the driving force behind the development of Alzheimer's disease ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging.Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease.Label-free live brain imaging and targeted patching with third-harmonic generation microscopy.Plaque-associated lipids in Alzheimer's diseased brain tissue visualized by nonlinear microscopy Enrichment of cholesterol in microdissected Alzheimer's disease senile plaques as assessed by mass spectrometry.Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.Cholesterol in brain disease: sometimes determinant and frequently implicated.Dietary cholesterol impairs memory and memory increases brain cholesterol and sulfatide levels.Cholesterol and pathological processes in Alzheimer's disease.Cholesterol in Alzheimer's disease and tauopathy.Emerging therapeutics for Alzheimer's disease: an avenue of hope.Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis.Apolipoprotein Abeta: black sheep in a good family.ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.Genetic basis of Alzheimer's dementia: role of mtDNA mutations.Alzheimer's disease and cholesterol: the fat connection.Effect of HMG-CoA reductase inhibitors on beta-amyloid peptide levels: implications for Alzheimer's disease.Apolipoprotein E and cholesterol in aging and disease in the brain Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease.A role for heme in Alzheimer's disease: heme binds amyloid beta and has altered metabolism.Classification and basic pathology of Alzheimer disease.How does diabetes accelerate Alzheimer disease pathology?Neurobiological aspects of Alzheimer's disease.Reciprocal regulation of cholesterol and beta amyloid at the subcellular level in Alzheimer's disease.The link between altered cholesterol metabolism and Alzheimer's disease.Lipidomics of Alzheimer's disease.Cholesterol potentiates beta-amyloid-induced toxicity in human neuroblastoma cells: involvement of oxidative stress.Novel 'inflammatory plaque' pathology in presenilin-1 Alzheimer's disease.Spatiotemporal changes of free cholesterol and neutral lipids after transient middle cerebral artery occlusion in rats.Accumulation of flotillin-1 in tangle-bearing neurones of Alzheimer's disease.Anti-amyloidogenic effect of Allium sativum in Alzheimer's transgenic model Tg2576.Cholesterol in the senile plaque: often mentioned, never seen.APP/Aβ structural diversity and Alzheimer's disease pathogenesis.Antiamnesic potential of Murraya koenigii leaves.Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro.The neuroprotective effect of two statins: simvastatin and pravastatin on a streptozotocin-induced model of Alzheimer's disease in rats.Insoluble alpha-synuclein in Alzheimer's disease without Lewy body formation.

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P2860

Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice.

http://www.wikidata.org/entity/Q43696734

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2001 nî lūn-bûn

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Cholesterol accumulates in sen ...... patients and in transgenic APP

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Cholesterol accumulates in sen ...... nd in transgenic APP(SW) mice.

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Cholesterol accumulates in sen ...... patients and in transgenic APP

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Cholesterol accumulates in sen ...... nd in transgenic APP(SW) mice.

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Cholesterol accumulates in sen ...... patients and in transgenic APP

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Cholesterol accumulates in sen ...... nd in transgenic APP(SW) mice.

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Journal of Neuropathology & Experimental Neurology

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Cholesterol accumulates in sen ...... nd in transgenic APP(SW) mice.

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P2093

Abdullah LI

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Crawford F

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Delledonne A

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Dickson DW

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Humphrey JA

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Sparks DL

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P2860

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

Functional rafts in cell membranes

Neuropathological stageing of Alzheimer-related changes

Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

The role of cholesterol in the biosynthesis of beta-amyloid.

Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease.

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.

Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging.

Apolipoprotein E alleles as risk factors in Alzheimer's disease.

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11487052

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Alzheimer's disease