Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.
about
A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism.Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibitionSplitting p63Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome SystemNF-kappaB pathway: a target for preventing beta-amyloid (Abeta)-induced neuronal damage and Abeta42 productionFunctional interplay between MDM2, p63/p73 and mutant p53MDM4 (MDMX) and its Transcript Variants.Differences in the transactivation domains of p53 family members: a computational study.SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53DNA-binding and transactivation activities are essential for TAp63 protein degradation.Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.The C-terminus of p63 contains multiple regulatory elements with different functions.Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin.Ubiquitin and ubiquitin-like modifications of the p53 family.p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis.p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma.The role of p63 in cancer, stem cells and cancer stem cells.Alterations of p63 and p73 in human cancers.The evolution of MDM2 family genes.Critical role for a central part of Mdm2 in the ubiquitylation of p53.The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63.The expression of p63 is associated with the differential stage in nasopharyngeal carcinoma and EBV infection.Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase.Monoclonal antibodies raised against Xenopus p53 interact with human p73
P2860
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P2860
Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
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2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
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2001年學術文章
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2001年學術文章
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name
Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.
@en
Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.
@nl
type
label
Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.
@en
Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.
@nl
prefLabel
Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.
@en
Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.
@nl
P2860
P356
P1433
P1476
Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.
@en
P2093
A G Jochemsen
N A Little
P2860
P2888
P304
P356
10.1038/SJ.ONC.1204615
P407
P577
2001-07-01T00:00:00Z
P5875
P6179
1049333091