Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.
about
A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expressionDown syndrome: searching for the genetic culpritsDYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 bindingMirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alphaDirect association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactionsPhosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinasesThe WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functionsRegulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylationGenome-wide association scan for five major dimensions of personalityThe selectivity of protein kinase inhibitors: a further updateDown Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 HomologuesA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factorsDynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrateβ-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sitesCharacterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTBDosage of the Abcg1-U2af1 region modifies locomotor and cognitive deficits observed in the Tc1 mouse model of Down syndromeDYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.Prolyl isomerase Pin1 regulates neuronal differentiation via β-cateninDYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survivalA chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibitionSelective inhibition of the kinase DYRK1A by targeting its folding processPrioritizing the development of mouse models for childhood brain disordersTargeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in miceDosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cyclePhosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration.Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc.Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1.Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A).A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes.Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome miceC. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.Meeting at the crossroads: common mechanisms in Fragile X and Down syndromeGene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for Down Syndrome screening.The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiationOverexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndromeThe transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase.
P2860
Q21284144-DE4027EE-5B2F-4070-96A2-DE690897AE5DQ22241596-A6A68AD7-0D70-426F-9631-E578626141EFQ24293338-63336E15-4C09-4682-BEBE-B71F9DB83301Q24295673-C78AE729-8578-47D8-8413-9B42B6EFD275Q24297221-771CC433-2D2B-41DC-824A-F6E3B0C95B1AQ24298852-4F13D2D3-52FA-4545-AE2A-261F9B51760EQ24302518-1F8F1AD7-34B9-4F8D-AD08-F5E4602DEE04Q24339194-7234EBD8-8F11-466D-A471-D9A9DD935E5CQ24608568-1209BF96-32AC-413F-9DF3-281E34FB376FQ24654622-8E3E652F-49FF-4561-BCEC-FD9322486D74Q27300997-89D545B8-7DB2-4AD3-A083-A822E6D6920CQ28079929-03C9F669-54CC-483E-8746-1C12D1B5585BQ28185216-A36144CF-1C31-4BF5-9E79-82417E8E19A7Q28205049-1847F5FB-21B8-432A-BC30-8A86A3041518Q28478075-B4B4B0AF-DD55-4C46-87F5-6256B7B75C33Q28478194-18A63C0B-0AA6-4111-B500-BD0BFCB59AB9Q28543589-B8003ACE-2573-44A5-B324-42C8CFD9037DQ28574593-6F40212F-BB37-4E49-8041-110ED58FAB79Q28586339-7ECFF216-243A-41B0-A014-6E365F8209E7Q28592229-9B47D8E0-370B-46FD-BD15-19C272168728Q28828212-50289A5D-56A7-43E2-8362-941C7BB36557Q28834235-B6C0BFBF-C4C6-42E7-8F5B-E42120C8E97DQ30366940-89509152-2616-4A61-AD16-A83114BAF80EQ30490193-EBCB2B7B-E504-4A76-AA3C-E1D79DCF19A6Q30531707-4A9B1C80-52F8-4A88-AFBE-D7316118ADDEQ30579297-140224B9-6B9A-4ED6-BFEE-C0BA1FDA32A4Q30754477-08D40A70-F7FE-4E62-BB83-64806FD65F4AQ31079724-55FC8C8E-E535-49D1-9C9F-017EF7606D6BQ31104439-2BBE975C-DBB8-4C91-A911-F4B3B05FF32FQ31164546-F28CBF67-F8E9-4367-AD4A-D576421DA3D9Q33325766-A64142EB-F363-4F68-960A-C399E4748067Q33354112-1206D6B2-E9A2-40A6-A938-B1DFFA196657Q33452667-5FE613D6-D4D1-4BD7-97AD-E38B82693D40Q33674369-598A0ECA-126B-4589-A8B6-3780872EF639Q33701707-F5A5C11C-EFE1-416E-9342-4E09EFBD24DDQ33874584-9158D78C-B15B-4E46-8B1B-8B689E45BB81Q33886427-15EB6F87-E1AE-4BDF-ADAA-4CD7D99ABFE3Q33952905-C0E436E1-6AB7-4A5C-A52A-1E1387E25DEEQ34133976-43FCFC6B-FFB5-4F95-9A9B-EB3B532126A1Q34154827-E10C0BA2-3D8B-4528-A6AB-F72F97258249
P2860
Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Neurodevelopmental delay, moto ...... rine model of Down's syndrome.
@en
Neurodevelopmental delay, moto ...... rine model of Down's syndrome.
@nl
type
label
Neurodevelopmental delay, moto ...... rine model of Down's syndrome.
@en
Neurodevelopmental delay, moto ...... rine model of Down's syndrome.
@nl
prefLabel
Neurodevelopmental delay, moto ...... rine model of Down's syndrome.
@en
Neurodevelopmental delay, moto ...... rine model of Down's syndrome.
@nl
P2093
P50
P356
P1476
Neurodevelopmental delay, moto ...... urine model of Down's syndrome
@en
P2093
C Baamonde
J R González
P304
P356
10.1093/HMG/10.18.1915
P577
2001-09-01T00:00:00Z