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DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 bindingCloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinasesDyrk1A expression pattern supports specific roles of this kinase in the adult central nervous systemThe junctional SR protein JP-45 affects the functional expression of the voltage-dependent Ca2+ channel Cav1.1Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors.Oocyte expression with injection of purified T7 RNA polymerase.Glutamate receptor mutations in psychiatric and neurodevelopmental disorders.Insights from mouse models to understand neurodegeneration in Down syndrome.Gene therapy for Down syndrome.Zinc transporter-1 concentrates at the postsynaptic density of hippocampal synapses.Rett-like Severe Encephalopathy Caused by a De Novo GRIN2B Mutation Is Attenuated by D-serine Dietary Supplement.Diseases of the Synaptic Vesicle: A Potential New Group of Neurometabolic Disorders Affecting Neurotransmission.The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers.Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons.Transduction of the scorpion toxin maurocalcine into cells. Evidence that the toxin crosses the plasma membraneMaurocalcine and domain A of the II-III loop of the dihydropyridine receptor Cav 1.1 subunit share common binding sites on the skeletal ryanodine receptor.Maurocalcine interacts with the cardiac ryanodine receptor without inducing channel modificationNeurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome.A store-operated Ca2+ influx activated in response to the depletion of thapsigargin-sensitive Ca2+ stores is developmentally regulated in embryonic cortical neurons from mice.Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome.Adenosine A1-A2A Receptor Heteromer as a Possible Target for Early-Onset Parkinson's Disease.Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formationPhosphoproteomic Alterations of Ionotropic Glutamate Receptors in the Hippocampus of the Ts65Dn Mouse Model of Down Syndrome.Caveolin-3 is a direct molecular partner of the Cav1.1 subunit of the skeletal muscle L-type calcium channelL-Serine dietary supplementation is associated with clinical improvement of loss-of-function GRIN2B-related pediatric encephalopathy
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Xavier Altafaj
@ast
Xavier Altafaj
@en
Xavier Altafaj
@es
Xavier Altafaj
@nl
type
label
Xavier Altafaj
@ast
Xavier Altafaj
@en
Xavier Altafaj
@es
Xavier Altafaj
@nl
prefLabel
Xavier Altafaj
@ast
Xavier Altafaj
@en
Xavier Altafaj
@es
Xavier Altafaj
@nl
P106
P21
P31
P496
0000-0002-7595-0647