Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks.
about
Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damagePolo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbodyHuman MMS21/NSE2 is a SUMO ligase required for DNA repairIrofulven induces replication-dependent CHK2 activation related to p53 statusHuman claspin is required for replication checkpoint controlPhosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domainMDC1 is coupled to activated CHK2 in mammalian DNA damage response pathwaysMediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint controlNFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage responseNFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathwaysPhosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointEpicatechin stimulates mitochondrial activity and selectively sensitizes cancer cells to radiationDepletion of the adaptor protein NCK increases UV-induced p53 phosphorylation and promotes apoptosis.Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response.DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53.ATM-NF-kappaB connection as a target for tumor radiosensitizationGenotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.Human TopBP1 ensures genome integrity during normal S phaseReplication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68.ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation.The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation.p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in miceIrreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell cultureDNA damage checkpoint kinase Chk2 triggers replicative senescence.Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cellsATM regulates ATR chromatin loading in response to DNA double-strand breaks.Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response.Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities.Candidate protein biodosimeters of human exposure to ionizing radiation.Modifying the function of DNA repair nanomachines for therapeutic benefit.DNA Damage Response is Prominent in Ovarian High-Grade Serous Carcinomas, Especially Those with Rsf-1 (HBXAP) Overexpression.Chk2 activation and phosphorylation-dependent oligomerization.Deficiency in DNA damage response, a new characteristic of cells infected with latent HIV-1.Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.A Ddc2-Rad53 fusion protein can bypass the requirements for RAD9 and MRC1 in Rad53 activation.DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage.Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling.
P2860
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P2860
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks.
description
2001 nî lūn-bûn
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2001年の論文
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
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name
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks.
@en
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks.
@nl
type
label
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks.
@en
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks.
@nl
prefLabel
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks.
@en
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks.
@nl
P2093
P2860
P356
P1476
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks.
@en
P2093
P2860
P304
47755-47758
P356
10.1074/JBC.C100587200
P407
P577
2001-10-19T00:00:00Z