Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase. - Wikidata - wikimedia - TriplyDB

Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase.

Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase.

http://www.wikidata.org/entity/Q46650258

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mAMSA resistant human topoisomerase IIbeta mutation G465D has reduced ATP hydrolysis activity.Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90 Structure of the N-terminal Gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysis Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI A domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase function Structure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activity Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks.Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue The use of divalent metal ions by type II topoisomerases.The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II.Targeting the transposase domain of the DNA repair component Metnase to enhance chemotherapy Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.E. coli Gyrase Fails to Negatively Supercoil Diaminopurine-Substituted DNA.Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome Probing conformational changes in human DNA topoisomerase IIα by pulsed alkylation mass spectrometry.PTEN stabilizes TOP2A and regulates the DNA decatenation Restoration of topoisomerase 2 function by complementation of defective monomers in Drosophila Cytotoxic effect and molecular docking of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide--a novel topoisomerase II inhibitor.The role of ATP-dependent machines in regulating genome topology.Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate.Coupling between ATP binding and DNA cleavage by DNA topoisomerase II: A unifying kinetic and structural mechanism.DNA topoisomerase II, genotoxicity, and cancer Analysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspective A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.Structural frameworks for considering microbial protein- and nucleic acid-dependent motor ATPases.DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.DNA topoisomerase II and its growing repertoire of biological functions.Antiviral activity of (+)-rutamarin against Kaposi's sarcoma-associated herpesvirus by inhibition of the catalytic activity of human topoisomerase II.Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery 2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway.Synthesis and Biological Evaluation of Novel Ursolic acid Derivatives as Potential Anticancer Prodrugs.Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II.DNA topoisomerase-targeting chemotherapeutics: what's new?The role of monovalent cations in the ATPase reaction of DNA gyrase.Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIα activity through ATP-competitive inhibition Integrating molecular docking, DFT and CoMFA/CoMSIA approaches for a series of naphthoquinone fused cyclic α-aminophosphonates that act as novel topoisomerase II inhibitors.Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II.SMS 2.0: an updated database to study the structural plasticity of short peptide fragments in non-redundant proteins.Discovery of mono- and disubstituted 1H-pyrazolo[3,4]pyrimidines and 9H-purines as catalytic inhibitors of human DNA topoisomerase IIα.

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P2860

Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase.

http://www.wikidata.org/entity/Q46650258

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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name

Nucleotide-dependent domain mo ...... an type IIA DNA topoisomerase.

@en

Nucleotide-dependent domain mo ...... an type IIA DNA topoisomerase.

@nl

type

label

Nucleotide-dependent domain mo ...... an type IIA DNA topoisomerase.

@en

Nucleotide-dependent domain mo ...... an type IIA DNA topoisomerase.

@nl

prefLabel

Nucleotide-dependent domain mo ...... an type IIA DNA topoisomerase.

@en

Nucleotide-dependent domain mo ...... an type IIA DNA topoisomerase.

@nl

P1433

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Journal of Biological Chemistry

P1476

Nucleotide-dependent domain mo ...... man type IIA DNA topoisomerase

@en

P2093

Gregory L Verdine

http://www.w3.org/2001/XMLSchema#string

Hua Wei

http://www.w3.org/2001/XMLSchema#string

Seth K Bechis

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P2860

DNA T OPOISOMERASES : Structure, Function, and Mechanism

The ATP-operated clamp of human DNA topoisomerase IIalpha: hyperstimulation of ATPase by "piggy-back" binding

Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Processing of X-ray diffraction data collected in oscillation mode

Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands

Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution.

Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187

Structure and mechanism of DNA topoisomerase II

Crystal structure of the breakage-reunion domain of DNA gyrase

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37041-37047

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scholarly article

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10.1074/JBC.M506520200

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44

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P478

280

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Alexander J Ruthenburg

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2005-08-12T00:00:00Z

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P698

16100112

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