Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins.
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Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disordersSignaling effect of amyloid-beta(42) on the processing of AbetaPPGenetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesisBehavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines.Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid -related Behavioral Deficits in a Mouse Model of Alzheimer DiseaseSpines, plasticity, and cognition in Alzheimer's model miceNicotinic ACh receptors as therapeutic targets in CNS disordersLoss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease.Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout miceDeletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's diseaseNeutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD MouseNeurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse modelAPP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis.Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status.Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1).Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 miceAmyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's diseaseLongitudinal analysis of the behavioral phenotype in a novel transgenic rat model of early stages of Alzheimer's disease.Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 mice.A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptidesChronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer's disease.The effects of cholesterol on learning and memory.Degenerative alterations in noradrenergic neurons of the locus coeruleus in Alzheimer's diseaseNatural amyloid-β oligomers acutely impair the formation of a contextual fear memory in miceOverexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production.Role of alpha7 nicotinic acetylcholine receptor in calcium signaling induced by prion protein interaction with stress-inducible protein 1.Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse modelUsing mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse modelsFunctional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptides.Insulin resistance in Alzheimer's disease.α7 Nicotinic receptor-mediated astrocytic gliotransmitter release: Aβ effects in a preclinical Alzheimer's mouse model.Building a more perfect beast: APP transgenic mice with neuronal loss.Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism.Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cellsSildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease.Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice
P2860
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P2860
Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Accelerated plaque accumulatio ...... nd amyloid precursor proteins.
@en
Accelerated plaque accumulatio ...... nd amyloid precursor proteins.
@nl
type
label
Accelerated plaque accumulatio ...... nd amyloid precursor proteins.
@en
Accelerated plaque accumulatio ...... nd amyloid precursor proteins.
@nl
prefLabel
Accelerated plaque accumulatio ...... nd amyloid precursor proteins.
@en
Accelerated plaque accumulatio ...... nd amyloid precursor proteins.
@nl
P2093
P2860
P356
P1476
Accelerated plaque accumulatio ...... nd amyloid precursor proteins.
@en
P2093
J David Sweatt
Kelly T Dineley
Xuefeng Xia
P2860
P304
22768-22780
P356
10.1074/JBC.M200164200
P407
P577
2002-03-23T00:00:00Z