Different substrate recognition motifs of human and trypanosome nucleobase transporters. Selective uptake of purine antimetabolites.
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Characterization of the transport mechanism and permeant binding profile of the uridine permease Fui1p of Saccharomyces cerevisiae.Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream formsReduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasisPredictive computational models of substrate binding by a nucleoside transporter.Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy.Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes.Symmetrical choline-derived dications display strong anti-kinetoplastid activity.Dissecting interactions between nucleosides and germination receptors in Bacillus cereus 569 spores.Insights to the evolution of Nucleobase-Ascorbate Transporters (NAT/NCS2 family) from the Cys-scanning analysis of xanthine permease XanQTrypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns.Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets.The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomesA plethora of targets, a paucity of drugs: progress towards the development of novel chemotherapies for human African trypanosomiasis.Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategyPurine and pyrimidine transport in pathogenic protozoa: from biology to therapy.Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptakeTransporters for drug delivery and as drug targets in parasitic protozoa.Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity.Nucleoside/nucleobase transporters: drug targets of the future?The nucleobase adenine as a signalling molecule in the kidney.Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.The Chemical Characterization of Nigerian Propolis samples and Their Activity Against Trypanosoma brucei.Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.Solution structures of purine base analogues 6-chloroguanine, 8-azaguanine and allopurinol.Chemical characterisation of Nigerian red propolis and its biological activity against Trypanosoma Brucei.9-(2'-Deoxy-2'-Fluoro-β-d-Arabinofuranosyl) Adenine Is a Potent Antitrypanosomal Adenosine Analogue That Circumvents Transport-Related Drug Resistance.Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines.Design and synthesis of a series of truncated neplanocin fleximers.Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human equilibrative nucleoside transporter and the human facilitative nucleobase transporter.Purine nucleobase transport in amastigotes of Leishmania mexicana: involvement in allopurinol uptakeUridine recognition motifs of human equilibrative nucleoside transporters 1 and 2 produced in Saccharomyces cerevisiae.Selective transport of a new class of purine antimetabolites by the protozoan parasite Trypanosoma brucei.Comparative substrate recognition by bacterial and fungal purine transporters of the NAT/NCS2 family.
P2860
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P2860
Different substrate recognition motifs of human and trypanosome nucleobase transporters. Selective uptake of purine antimetabolites.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Different substrate recognitio ...... ake of purine antimetabolites.
@en
Different substrate recognitio ...... ake of purine antimetabolites.
@nl
type
label
Different substrate recognitio ...... ake of purine antimetabolites.
@en
Different substrate recognitio ...... ake of purine antimetabolites.
@nl
prefLabel
Different substrate recognitio ...... ake of purine antimetabolites.
@en
Different substrate recognitio ...... ake of purine antimetabolites.
@nl
P2860
P356
P1476
Different substrate recognitio ...... ake of purine antimetabolites.
@en
P2093
Denise Candlish
Lynsey J M Wallace
P2860
P304
26149-26156
P356
10.1074/JBC.M202835200
P407
P577
2002-05-09T00:00:00Z