Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds.
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Combinatorial biosynthesis of antitumor indolocarbazole compoundsEnzymatic methods for glyco(diversification/randomization) of drugs and small moleculesNatural-product sugar biosynthesis and enzymatic glycodiversification.Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coliInactivation of gilGT, encoding a C-glycosyltransferase, and gilOIII, encoding a P450 enzyme, allows the details of the late biosynthetic pathway to gilvocarcin V to be delineated.Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferaseCharacterization of the TDP-D-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-D-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate.Engineered biosynthesis of gilvocarcin analogues with altered deoxyhexopyranose moieties.The impact of enzyme engineering upon natural product glycodiversificationCombinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexosesDevelopment of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates.The enzymology of combinatorial biosynthesis.Ketoolivosyl-tetracenomycin C: a new ketosugar bearing tetracenomycin reveals new insight into the substrate flexibility of glycosyltransferase ElmGTA novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.Investigating Mithramycin deoxysugar biosynthesis: enzymatic total synthesis of TDP-D-olivose.Tailoring pathway modularity in the biosynthesis of erythromycin analogs heterologously engineered in E. coliType II polyketide synthases: gaining a deeper insight into enzymatic teamwork.Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivityGeneration of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.Hutchinson's legacy: keeping on polyketide biosynthesis.Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.Glycosyltransferases: mechanisms and applications in natural product development.Production of the potent antibacterial polyketide erythromycin C in Escherichia coli.Metabolic engineering--a genetic toolbox for small molecule organic synthesis.Two-step enzymatic synthesis of 6-deoxy-L-psicose.Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis.The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme.C-glycosylation of anhydrotetracycline scaffold with SsfS6 from the SF2575 biosynthetic pathway.Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins.Biosynthesis of 2-deoxysugars using whole-cell catalyst expressing 2-deoxy-D-ribose 5-phosphate aldolase.Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities.Enzymatic production of three 6-deoxy-aldohexoses from L-rhamnose.
P2860
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P2860
Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Engineering deoxysugar biosynt ...... cosylated bioactive compounds.
@en
Engineering deoxysugar biosynt ...... cosylated bioactive compounds.
@nl
type
label
Engineering deoxysugar biosynt ...... cosylated bioactive compounds.
@en
Engineering deoxysugar biosynt ...... cosylated bioactive compounds.
@nl
prefLabel
Engineering deoxysugar biosynt ...... cosylated bioactive compounds.
@en
Engineering deoxysugar biosynt ...... cosylated bioactive compounds.
@nl
P2093
P1476
Engineering deoxysugar biosynt ...... cosylated bioactive compounds.
@en
P2093
Ignacio Aguirrezabalaga
José A Salas
Leticia Rodríguez
Nerea Allende
P304
P356
10.1016/S1074-5521(02)00154-0
P577
2002-06-01T00:00:00Z