Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli.
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Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3Postpartum remodeling, lactation, and breast cancer risk: summary of a National Cancer Institute-sponsored workshopTSC-22D1 isoforms have opposing roles in mammary epithelial cell survivalDispersal of an ancient retroposon in the TP53 promoter of Bovidae: phylogeny, novel mechanisms, and potential implications for cow milk persistencyAcute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland functionLactation failure in Src knockout mice is due to impaired secretory activation.Mechanical strain induces involution-associated events in mammary epithelial cells.A dual role for oncostatin M signaling in the differentiation and death of mammary epithelial cells in vivo.Regulation and function of signal transducer and activator of transcription 3.Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression.Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.Cleavage of Histone 3 by Cathepsin D in the involuting mammary gland.Mammary gland growth factors: roles in normal development and in cancer.TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence.Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner.Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilizationStat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.Loss of protein kinase C delta alters mammary gland development and apoptosis.TGF-beta promotes cell death and suppresses lactation during the second stage of mammary involutionInvolution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ.MicroRNA expression profiling of lactating mammary gland in divergent phenotype swine breeds.Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cellsTargeting a cell state common to triple-negative breast cancersSignal transducer and activator of transcription 3 and the phosphatidylinositol 3-kinase regulatory subunits p55α and p50α regulate autophagy in vivo.Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activationThe two faces of Janus kinases and their respective STATs in mammary gland development and cancerApoptosis regulation in the mammary gland.Singleminded-2s (Sim2s) promotes delayed involution of the mouse mammary gland through suppression of Stat3 and NFκBNucling, a novel apoptosis-associated protein, controls mammary gland involution by regulating NF-κB and STAT3.Influenza Transmission in the Mother-Infant Dyad Leads to Severe Disease, Mammary Gland Infection, and Pathogenesis by Regulating Host Responses.Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes.Information networks in the mammary gland.Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression.Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and MetastasisThe BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.ATG proteins mediate efferocytosis and suppress inflammation in mammary involution.Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer.STAT signaling in mammary gland differentiation, cell survival and tumorigenesisMammary involution and breast cancer risk: transgenic models and clinical studies.
P2860
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P2860
Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Deletion of Stat3 blocks mamma ...... absence of lactogenic stimuli.
@en
Deletion of Stat3 blocks mamma ...... absence of lactogenic stimuli.
@nl
type
label
Deletion of Stat3 blocks mamma ...... absence of lactogenic stimuli.
@en
Deletion of Stat3 blocks mamma ...... absence of lactogenic stimuli.
@nl
prefLabel
Deletion of Stat3 blocks mamma ...... absence of lactogenic stimuli.
@en
Deletion of Stat3 blocks mamma ...... absence of lactogenic stimuli.
@nl
P2093
P356
P1433
P1476
Deletion of Stat3 blocks mamma ...... absence of lactogenic stimuli
@en
P2093
Brian Bierie
Regina Raz
Robin C Humphreys
P304
P356
10.1210/EN.2002-220224
P407
P577
2002-09-01T00:00:00Z