Evidence for direct attack by hydroxide in phosphodiester hydrolysis.
about
Biological phosphoryl-transfer reactions: understanding mechanism and catalysisAlkaline phosphatase mono- and diesterase reactions: comparative transition state analysisAdvances in kinetic isotope effect measurement techniques for enzyme mechanism studyInaccuracies in selected ion monitoring determination of isotope ratios obviated by profile acquisition: nucleotide 18O/16O measurements.QM/MM analysis suggests that Alkaline Phosphatase (AP) and nucleotide pyrophosphatase/phosphodiesterase slightly tighten the transition state for phosphate diester hydrolysis relative to solution: implication for catalytic promiscuity in the AP supeInsight into the phosphodiesterase mechanism from combined QM/MM free energy simulations.Mechanistic insights into RNA transphosphorylation from kinetic isotope effects and linear free energy relationships of model reactions.Evidence that binding of C5 protein to P RNA enhances ribozyme catalysis by influencing active site metal ion affinity.The bacterial ribonuclease P holoenzyme requires specific, conserved residues for efficient catalysis and substrate positioning.Mechanistic study of protein phosphatase-1 (PP1), a catalytically promiscuous enzymeExperimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation.Experimental analyses of the chemical dynamics of ribozyme catalysisMechanism and transition state structure of aryl methylphosphonate esters doubly coordinated to a dinuclear cobalt(III) center.Identification of catalytic metal ion ligands in ribozymes.An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals.Why nature really chose phosphate.Integration of kinetic isotope effect analyses to elucidate ribonuclease mechanism.Kinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base.The effects of sulfur substitution for the nucleophile and bridging oxygen atoms in reactions of hydroxyalkyl phosphate esters.Altered transition state for the reaction of an RNA model catalyzed by a dinuclear zinc(II) catalyst.Crystallization kinetics of cerium oxide nanoparticles formed by spontaneous, room-temperature hydrolysis of cerium(iv) ammonium nitrate in light and heavy water.Mitochondrial DNA, nuclear context, and the risk for carcinogenesis.Mechanistic investigation of the cleavage of phosphodiester catalyzed by a symmetrical oxyimine-based macrocyclic dinuclear zinc complex: a DFT study.Alkaline hydrolysis of ethylene phosphate: an ab initio study by supermolecule model and polarizable continuum approach.The Mechanism of Cleavage and Isomerisation of RNA Promoted by an Efficient Dinuclear Zn2+ Complex
P2860
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P2860
Evidence for direct attack by hydroxide in phosphodiester hydrolysis.
description
2002 nî lūn-bûn
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2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
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2002年学术文章
@zh-cn
2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Evidence for direct attack by hydroxide in phosphodiester hydrolysis.
@en
Evidence for direct attack by hydroxide in phosphodiester hydrolysis.
@nl
type
label
Evidence for direct attack by hydroxide in phosphodiester hydrolysis.
@en
Evidence for direct attack by hydroxide in phosphodiester hydrolysis.
@nl
prefLabel
Evidence for direct attack by hydroxide in phosphodiester hydrolysis.
@en
Evidence for direct attack by hydroxide in phosphodiester hydrolysis.
@nl
P2093
P356
P1476
Evidence for direct attack by hydroxide in phosphodiester hydrolysis.
@en
P2093
Adam G Cassano
Michael E Harris
Vernon E Anderson
P304
10964-10965
P356
10.1021/JA020823J
P407
P577
2002-09-01T00:00:00Z