Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol.
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Anchorless 23-230 PrPC interactomics for elucidation of PrPC protective roleProtein folding by the effects of macromolecular crowdingPrion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage responseThe delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologyNeuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment.Endoplasmic Reticulum Stress Is a Determinant of Retrovirus-Induced Spongiform NeurodegenerationExpression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunctionSolvent microenvironments and copper binding alters the conformation and toxicity of a prion fragmentRecognition of 27-class protein folds by adding the interaction of segments and motif information.Changes in protein structure and distribution observed at pre-clinical stages of scrapie pathogenesis.The recognition of multi-class protein folds by adding average chemical shifts of secondary structure elementsLethal recessive myelin toxicity of prion protein lacking its central domain.Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.Cytoplasmic prion protein induces forebrain neurotoxicityGetting a grip on prions: oligomers, amyloids, and pathological membrane interactions.Molecular interaction of TPPP with PrP antagonized the CytoPrP-induced disruption of microtubule structures and cytotoxicityThe expanding universe of prion diseases.Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway.Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegenerationIn vitro and in vivo neurotoxicity of prion protein oligomers.Molecular distinction between pathogenic and infectious properties of the prion protein.Endoplasmic reticulum stress, PrP trafficking, and neurodegeneration.Pathologic prion protein infects cells by lipid-raft dependent macropinocytosisPrion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assayPersistent hijacking of brain proteasomes in HIV-associated dementia.The efficiency of protein compartmentalization into the secretory pathway.Perturbation of endoplasmic reticulum homeostasis facilitates prion replication.Context dependent neuroprotective properties of prion protein (PrP).Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.Cell type-specific neuroprotective activity of untranslocated prion protein.Redox control of prion and disease pathogenesis.Biological characteristics of Chinese hamster ovary cells transfected with bovine PrnpCytosolic PrP can participate in prion-mediated toxicityDirect observation of multiple misfolding pathways in a single prion protein moleculeCompartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo.Cell-specific metabolism and pathogenesis of transmembrane prion protein.Prion protein in Caenorhabditis elegans: Distinct models of anti-BAX and neuropathology.Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion diseaseSelective re-routing of prion protein to proteasomes and alteration of its vesicular secretion prevent PrP(Sc) formation.
P2860
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P2860
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol.
@en
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol.
@nl
type
label
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol.
@en
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol.
@nl
prefLabel
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol.
@en
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol.
@nl
P356
P1433
P1476
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol.
@en
P2093
Robert Wollmann
P304
P356
10.1126/SCIENCE.1073725
P407
P577
2002-10-17T00:00:00Z