Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors.
about
MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNAVariant base excision repair proteins: contributors to genomic instabilityOxidative stress, mitochondrial dysfunction, and agingFunctional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposisPhosphorylation of human oxoguanine DNA glycosylase (alpha-OGG1) modulates its function8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalpha.Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylaseRepair of oxidative DNA damage and cancer: recent progress in DNA base excision repairCellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cellsPathways for repairing and tolerating the spectrum of oxidative DNA lesionsBase excision repair and cancerBinary complex crystal structure of DNA polymerase reveals multiple conformations of the templating 8-oxoguanine lesionPCNA monoubiquitylation and DNA polymerase eta ubiquitin-binding domain are required to prevent 8-oxoguanine-induced mutagenesis in Saccharomyces cerevisiae.Base excision repairDNA replication fidelity and cancerA role for oxidized DNA precursors in Huntington's disease-like striatal neurodegenerationsiRNA screening of a targeted library of DNA repair factors in HIV infection reveals a role for base excision repair in HIV integrationPeto's Paradox: evolution's prescription for cancer preventionBase-excision repair of oxidative DNA damageEfficiency of Base Excision Repair of Oxidative DNA Damage and Its Impact on the Risk of Colorectal Cancer in the Polish PopulationAnalysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model.Characterization of oxidative guanine damage and repair in mammalian telomeres.The Mutyh base excision repair gene influences the inflammatory response in a mouse model of ulcerative colitis.Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway.No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient miceDeletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis.Mitochondrial base excision repair assaysRole of oxidatively induced DNA lesions in human pathogenesisBAX and tumor suppressor TRP53 are important in regulating mutagenesis in spermatogenic cells in mice.8-oxoguanine causes spontaneous de novo germline mutations in mice.Use of conventional and -omics based methods for health claims of dietary antioxidants: a critical overview.8-Hydroxyguanine: From its discovery in 1983 to the present status.New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1).Specialized mismatch repair function of Glu339 in the Phe-X-Glu motif of yeast Msh6Functional characterization of human MutY homolog (hMYH) missense mutation (R231L) that is linked with hMYH-associated polyposis.Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34Folate and colorectal cancer in rodents: a model of DNA repair deficiency.DNA sequence context effects on the glycosylase activity of human 8-oxoguanine DNA glycosylase.Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells.
P2860
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P2860
Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Deficiencies in mouse Myh and ...... K-ras oncogene in lung tumors.
@en
Deficiencies in mouse Myh and ...... K-ras oncogene in lung tumors.
@nl
type
label
Deficiencies in mouse Myh and ...... K-ras oncogene in lung tumors.
@en
Deficiencies in mouse Myh and ...... K-ras oncogene in lung tumors.
@nl
prefLabel
Deficiencies in mouse Myh and ...... K-ras oncogene in lung tumors.
@en
Deficiencies in mouse Myh and ...... K-ras oncogene in lung tumors.
@nl
P2093
P1433
P1476
Deficiencies in mouse Myh and ...... K-ras oncogene in lung tumors.
@en
P2093
Cristina Cunanan
Darryl Shibata
Deborah E Barnes
Hanjing Yang
Jeffrey H Miller
Kimberly Okamoto
Michael McIlhatton
Richard Fishel
P304
P356
10.1158/0008-5472.CAN-03-3834
P407
P577
2004-05-01T00:00:00Z