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A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell deathDisease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagyPaired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomesUBA1: At the Crossroads of Ubiquitin Homeostasis and NeurodegenerationAn intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregationThe parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodiesAggresome formation and neurodegenerative diseases: therapeutic implicationsProteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chainsProteomic characterization of an isolated fraction of synthetic proteasome inhibitor (PSI)-induced inclusions in PC12 cells might offer clues to aggresomes as a cellular defensive response against proteasome inhibition by PSI.Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.Aggresomes do not represent a general cellular response to protein misfolding in mammalian cellsMisfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complexProtein quality control during erythropoiesis and hemoglobin synthesisMitochondrial abnormality associates with type-specific neuronal loss and cell morphology changes in the pedunculopontine nucleus in Parkinson diseaseThe role of ubiquitin in autophagy-dependent protein aggregate processingSequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology.Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibersAddition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates.Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearanceEffect of lysosomal and ubiquitin-proteasome system dysfunction on the abnormal aggregation of α-synuclein in PC12 cells.Plasma Prolidase Activity and Oxidative Stress in Patients with Parkinson's DiseaseThe aggravating role of the ubiquitin-proteasome system in neurodegeneration.Isolation of aggresomes and other large aggregatesProtein quality control: the who's who, the where's and therapeutic escapes.The role of ubiquitin-protein ligases in neurodegenerative disease.Drug discovery in Parkinson's disease-Update and developments in the use of cellular models.Historical survey on chromatoid body researchThe Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates.Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery.Proteomic identification of novel proteins associated with Lewy bodies.The activation sequence of cellular protein handling systems after proteasomal inhibition in dopaminergic cells.Targeting the progression of Parkinson's disease.Clinical, histological and genetic characterization of reducing body myopathy caused by mutations in FHL1.Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps.Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cellsA sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1AA critical evaluation of the ubiquitin-proteasome system in Parkinson's diseaseProteomic analysis of mitochondrial dysfunction in neurodegenerative diseases.The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration
P2860
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P2860
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Aggresome-related biogenesis of Lewy bodies.
@en
Aggresome-related biogenesis of Lewy bodies.
@nl
type
label
Aggresome-related biogenesis of Lewy bodies.
@en
Aggresome-related biogenesis of Lewy bodies.
@nl
prefLabel
Aggresome-related biogenesis of Lewy bodies.
@en
Aggresome-related biogenesis of Lewy bodies.
@nl
P2093
P2860
P1476
Aggresome-related biogenesis of Lewy bodies.
@en
P2093
Daniel P Perl
Kevin St P McNaught
P Shashidharan
Peter Jenner
P2860
P304
P356
10.1046/J.1460-9568.2002.02301.X
P407
P577
2002-12-01T00:00:00Z