Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. - Wikidata - wikimedia - TriplyDB

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.

http://www.wikidata.org/entity/Q44270458

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Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain Protein phosphatases and Alzheimer's disease Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients Signaling effect of amyloid-beta(42) on the processing of AbetaPP Mechanisms of Aβ Clearance and Degradation by Glial Cells Synaptic Cell Adhesion Molecules in Alzheimer's Disease Amyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET Imaging G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs Advances in development of fluorescent probes for detecting amyloid-β aggregates Trafficking regulation of proteins in Alzheimer's disease Platelets and Alzheimer's disease: Potential of APP as a biomarker Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's disease APP processing in Alzheimer's disease Development and Structural Modification of BACE1 Inhibitors Proteolytic processing of Alzheimer's β-amyloid precursor protein BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease BACE1 expression and activity: relevance in Alzheimer's disease Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system Modulators of γ-secretase activity can facilitate the toxic side-effects and pathogenesis of Alzheimer's disease The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1 Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.COL25A1 triggers and promotes Alzheimer's disease-like pathology in vivo.Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia.Vanillic acid attenuates Aβ1-42-induced oxidative stress and cognitive impairment in mice.Increased γ-secretase activity in idiopathic normal pressure hydrocephalus patients with β-amyloid pathology.Demonstration of an anti-oxidative stress mechanism of quetiapine: implications for the treatment of Alzheimer's disease.Palmitate Increases β-site AβPP-Cleavage Enzyme 1 Activity and Amyloid-β Genesis by Evoking Endoplasmic Reticulum Stress and Subsequent C/EBP Homologous Protein Activation.Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle BACE1 and BACE2 enzymatic activities in Alzheimer's disease.Occludin deficiency with BACE1 elevation in cerebral amyloid angiopathy.

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P2860

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.

http://www.wikidata.org/entity/Q44270458

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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name

Elevated beta-secretase expres ...... in sporadic Alzheimer disease.

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Elevated beta-secretase expres ...... in sporadic Alzheimer disease.

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type

label

Elevated beta-secretase expres ...... in sporadic Alzheimer disease.

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Elevated beta-secretase expres ...... in sporadic Alzheimer disease.

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prefLabel

Elevated beta-secretase expres ...... in sporadic Alzheimer disease.

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Elevated beta-secretase expres ...... in sporadic Alzheimer disease.

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Nature Medicine

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Elevated beta-secretase expres ...... in sporadic Alzheimer disease.

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P2093

Donald Price

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Kristina Lindholm

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Li-Bang Yang

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Lucia Sue

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Martin Citron

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Philip Wong

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Rena Li

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Riqiang Yan

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Weiming Xia

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Xiao-Li Yang

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3-4

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scholarly article

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10.1038/NM0103-3

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1

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10961650

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12514700

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Alzheimer's disease