Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion.
about
Comparative genomics and molecular dynamics of DNA repeats in eukaryotesContinuous and periodic expansion of CAG repeats in Huntington's disease R6/1 miceRapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiaeReconstituted Okazaki fragment processing indicates two pathways of primer removal.Expression and biochemical characterization of the Plasmodium falciparum DNA repair enzyme, flap endonuclease-1 (PfFEN-1)Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesisAn evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic developmentInstability of CTG repeats is governed by the position of a DNA base lesion through base excision repairTissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivoHMGB1: roles in base excision repair and related function.Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeatsA 5', 8-cyclo-2'-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase βPostreplication repair inhibits CAG.CTG repeat expansions in Saccharomyces cerevisiae.Repeat instability during DNA repair: Insights from model systemsHaploinsufficiency of yeast FEN1 causes instability of expanded CAG/CTG tracts in a length-dependent manner.DNA base excision repair: a mechanism of trinucleotide repeat expansion.Msh2-Msh3 interferes with Okazaki fragment processing to promote trinucleotide repeat expansions.Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1.Crosstalk between MSH2-MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair.Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stabilityCoordination between polymerase beta and FEN1 can modulate CAG repeat expansion.Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion.Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes.Close encounters: Moving along bumps, breaks, and bubbles on expanded trinucleotide tracts.Saccharomyces cerevisiae Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats.Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein.Genome-wide demethylation destabilizes CTG.CAG trinucleotide repeats in mammalian cells.Human Bloom protein stimulates flap endonuclease 1 activity by resolving DNA secondary structure.Triplet repeat expansion generated by DNA slippage is suppressed by human flap endonuclease 1.Fen1 does not control somatic hypermutability of the (CTG)(n)*(CAG)(n) repeat in a knock-in mouse model for DM1.
P2860
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P2860
Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion.
description
2003 nî lūn-bûn
@nan
2003年の論文
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2003年学术文章
@wuu
2003年学术文章
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2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
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name
Analysis of human flap endonuc ...... vent triplet repeat expansion.
@en
Analysis of human flap endonuc ...... vent triplet repeat expansion.
@nl
type
label
Analysis of human flap endonuc ...... vent triplet repeat expansion.
@en
Analysis of human flap endonuc ...... vent triplet repeat expansion.
@nl
prefLabel
Analysis of human flap endonuc ...... vent triplet repeat expansion.
@en
Analysis of human flap endonuc ...... vent triplet repeat expansion.
@nl
P2860
P356
P1476
Analysis of human flap endonuc ...... vent triplet repeat expansion.
@en
P2093
Robert A Bambara
P2860
P304
13728-13739
P356
10.1074/JBC.M212061200
P407
P577
2003-01-28T00:00:00Z