Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability
about
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication forkEvidence for a role of FEN1 in maintaining mitochondrial DNA integrityThe flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.Genetic instability induced by overexpression of DNA ligase I in budding yeast.The Rad27 (Fen-1) nuclease inhibits Ty1 mobility in Saccharomyces cerevisiae.Endonuclease G: a role for the enzyme in recombination and cellular proliferationComplex minisatellite rearrangements generated in the total or partial absence of Rad27/hFEN1 activity occur in a single generation and are Rad51 and Rad52 dependent.Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instabilityHaploinsufficiency of yeast FEN1 causes instability of expanded CAG/CTG tracts in a length-dependent manner.Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast geneticsComplementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants.S-phase checkpoint pathways stimulate the mobility of the retrovirus-like transposon Ty1.A saccharomyces cerevisiae RNase H2 interaction network functions to suppress genome instabilityHuman replication factor C stimulates flap endonuclease 1DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phaseStimulation of eukaryotic flap endonuclease-1 activities by proliferating cell nuclear antigen (PCNA) is independent of its in vitro interaction via a consensus PCNA binding region.Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion.Human Bloom protein stimulates flap endonuclease 1 activity by resolving DNA secondary structure.
P2860
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P2860
Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Functional analysis of human F ...... d its role in genome stability
@ast
Functional analysis of human F ...... d its role in genome stability
@en
Functional analysis of human F ...... d its role in genome stability
@nl
type
label
Functional analysis of human F ...... d its role in genome stability
@ast
Functional analysis of human F ...... d its role in genome stability
@en
Functional analysis of human F ...... d its role in genome stability
@nl
prefLabel
Functional analysis of human F ...... d its role in genome stability
@ast
Functional analysis of human F ...... d its role in genome stability
@en
Functional analysis of human F ...... d its role in genome stability
@nl
P356
P1476
Functional analysis of human F ...... d its role in genome stability
@en
P2093
P304
P356
10.1093/HMG/8.12.2263
P407
P577
1999-11-01T00:00:00Z