Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing.
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Integration of troponin I phosphorylation with cardiac regulatory networksCardiac thin filament regulation and the Frank-Starling mechanismPhosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytesCardiac thin filament regulationPerturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutationsLength-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylationTroponin T modulates sarcomere length-dependent recruitment of cross-bridges in cardiac muscle.Cardiac myosin-binding protein-C phosphorylation and cardiac functionA novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysisSites of intra- and intermolecular cross-linking of the N-terminal extension of troponin I in human cardiac whole troponin complex.Protein kinase A-mediated phosphorylation of cMyBP-C increases proximity of myosin heads to actin in resting myocardium.Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins.Myofilament length dependent activationGenotype-specific pathogenic effects in human dilated cardiomyopathy.Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kineticsTroponin I phosphorylation in human myocardium in health and disease.Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy.Protein kinase A-induced myofilament desensitization to Ca(2+) as a result of phosphorylation of cardiac myosin-binding protein CFunctional effects of a tropomyosin mutation linked to FHC contribute to maladaptation during acidosisLength-dependent changes in contractile dynamics are blunted due to cardiac myosin binding protein-C ablation.A mathematical model of the mouse ventricular myocyte contraction.Familial hypertrophic cardiomyopathy related cardiac troponin C L29Q mutation alters length-dependent activation and functional effects of phosphomimetic troponin I*The regulation of troponins I, C and ANP by GATA4 and Nkx2-5 in heart of hibernating thirteen-lined ground squirrels, Ictidomys tridecemlineatus.A Spatially Detailed Model of Isometric Contraction Based on Competitive Binding of Troponin I Explains Cooperative Interactions between Tropomyosin and Crossbridges.Magnitude of length-dependent changes in contractile properties varies with titin isoform in rat ventricles.AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function.Length and PKA Dependence of Force Generation and Loaded Shortening in Porcine Cardiac MyocytesMechanisms of the Frank-Starling law of the heart: the beat goes on.Enhanced Ca2+ binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges.Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium.ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease.Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner.Troponin and titin coordinately regulate length-dependent activation in skinned porcine ventricular muscleCardiac Myosin Binding Protein-C Phosphorylation Modulates Myofilament Length-Dependent ActivationTitin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins.Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.Cardiac function and modulation of sarcomeric function by length.The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation.Sarcomere length dependence of power output is increased after PKA treatment in rat cardiac myocytes
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P2860
Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年學術文章
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name
Troponin I in the murine myoca ...... ion and interfilament spacing.
@en
Troponin I in the murine myoca ...... ion and interfilament spacing.
@nl
type
label
Troponin I in the murine myoca ...... ion and interfilament spacing.
@en
Troponin I in the murine myoca ...... ion and interfilament spacing.
@nl
prefLabel
Troponin I in the murine myoca ...... ion and interfilament spacing.
@en
Troponin I in the murine myoca ...... ion and interfilament spacing.
@nl
P2093
P2860
P1476
Troponin I in the murine myoca ...... ion and interfilament spacing.
@en
P2093
Anne F Martin
Beata M Wolska
Eias E Jweied
John P Konhilas
Pieter P de Tombe
R John Solaro
Thomas C Irving
P2860
P304
P356
10.1113/JPHYSIOL.2002.038117
P407
P577
2003-01-24T00:00:00Z