Differential influence of nucleoside analog-resistance mutations K65R and L74V on the overall mutation rate and error specificity of human immunodeficiency virus type 1 reverse transcriptase.
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Viral quasispecies evolutionStructural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir ResistanceInfluence of reverse transcriptase variants, drugs, and Vpr on human immunodeficiency virus type 1 mutant frequencies.Genotypic testing for human immunodeficiency virus type 1 drug resistance.Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication.Probing the active site steric flexibility of HIV-1 reverse transcriptase: different constraints for DNA- versus RNA-templated synthesis.A novel genetic pathway of human immunodeficiency virus type 1 resistance to stavudine mediated by the K65R mutation.Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection.Substitution of alanine for tyrosine-64 in the fingers subdomain of M-MuLV reverse transcriptase impairs strand displacement synthesis and blocks viral replication in vivo.Lys66 residue as a determinant of high mismatch extension and misinsertion rates of HIV-1 reverse transcriptase.Antiretroviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase increase template-switching frequency.Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.In vitro fidelity of the prototype primate foamy virus (PFV) RT compared to HIV-1 RT.Comparative analysis of in vitro processivity of HIV-1 reverse transcriptases containing mutations 65R, 74V, 184V and 65R+74V.Mutation rates and intrinsic fidelity of retroviral reverse transcriptases.The high cost of fidelity.The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance.K65R and K65A substitutions in HIV-1 reverse transcriptase enhance polymerase fidelity by decreasing both dNTP misinsertion and mispaired primer extension efficiencies.A mutation in the primer grip region of HIV-1 reverse transcriptase that confers reduced fidelity of DNA synthesisMolecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity.Diminished RNA primer usage associated with the L74V and M184V mutations in the reverse transcriptase of human immunodeficiency virus type 1 provides a possible mechanism for diminished viral replication capacity.Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis.Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases.AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase.Comparative selection of the K65R and M184V/I mutations in human immunodeficiency virus type 1-infected patients enrolled in a trial of first-line triple-nucleoside analog therapy (Tonus IMEA 021).The role of phenylalanine-119 of the reverse transcriptase of mouse mammary tumour virus in DNA synthesis, ribose selection and drug resistance.Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase.Identification of a simian immunodeficiency virus reverse transcriptase variant with enhanced replicational fidelity in the late stage of viral infection.Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses.Mechanism-based suppression of dideoxynucleotide resistance by K65R human immunodeficiency virus reverse transcriptase using an alpha-boranophosphate nucleoside analogue.Structural determinants of slippage-mediated mutations by human immunodeficiency virus type 1 reverse transcriptase.Transcriptional inaccuracy threshold attenuates differences in RNA-dependent DNA synthesis fidelity between retroviral reverse transcriptases.
P2860
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P2860
Differential influence of nucleoside analog-resistance mutations K65R and L74V on the overall mutation rate and error specificity of human immunodeficiency virus type 1 reverse transcriptase.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Differential influence of nucl ...... type 1 reverse transcriptase.
@en
Differential influence of nucl ...... type 1 reverse transcriptase.
@nl
type
label
Differential influence of nucl ...... type 1 reverse transcriptase.
@en
Differential influence of nucl ...... type 1 reverse transcriptase.
@nl
prefLabel
Differential influence of nucl ...... type 1 reverse transcriptase.
@en
Differential influence of nucl ...... type 1 reverse transcriptase.
@nl
P2093
P356
P1476
Differential influence of nucl ...... s type 1 reverse transcriptase
@en
P2093
P304
27037-27044
P356
10.1074/JBC.M002881200
P407
P577
2000-09-01T00:00:00Z