Modeling of Ca2+ flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores.
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Phase transitions in the multi-cellular regulatory behavior of pancreatic islet excitabilityMathematical model of metabolism and electrophysiology of amino acid and glucose stimulated insulin secretion: in vitro validation using a β-cell lineSubplasmalemmal Ca(2+) measurements in mouse pancreatic beta cells support the existence of an amplifying effect of glucose on insulin secretionSlow oscillations of KATP conductance in mouse pancreatic islets provide support for electrical bursting driven by metabolic oscillations.Evidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets.Direct measurements of oscillatory glycolysis in pancreatic islet β-cells using novel fluorescence resonance energy transfer (FRET) biosensors for pyruvate kinase M2 activityGlucose modulates [Ca2+]i oscillations in pancreatic islets via ionic and glycolytic mechanisms.Metabolic oscillations in pancreatic islets depend on the intracellular Ca2+ level but not Ca2+ oscillationsGlucose sensing in the pancreatic beta cell: a computational systems analysis.Lessons from models of pancreatic beta cells for engineering glucose-sensing cellsModeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+Modeling K,ATP--dependent excitability in pancreatic islets.Electrical bursting, calcium oscillations, and synchronization of pancreatic isletsGlucose stimulates calcium-activated chloride secretion in small intestinal cells.Calcium and Metabolic Oscillations in Pancreatic Islets: Who's Driving the Bus?(*)Ionic mechanisms and Ca2+ dynamics underlying the glucose response of pancreatic β cells: a simulation study.Dynamical systems theory in physiologyCoupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysisDisruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerancePancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational AnalysisBursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms.Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions.Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERSA computational systems analysis of factors regulating α cell glucagon secretion.Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes.Use of virtual cell in studies of cellular dynamics.Phase Analysis of Metabolic Oscillations and Membrane Potential in Pancreatic Islet β-Cells.Ca2+ Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity.β-Cell subcellular localization of glucose-stimulated Mn uptake by X-ray fluorescence microscopy: implications for pancreatic MRI.MATLAB implementation of a dynamic clamp with bandwidth of >125 kHz capable of generating I Na at 37 °C.Ion channels and regulation of insulin secretion in human β-cells: a computational systems analysisThe hyperbolic effect of density and strength of inter beta-cell coupling on islet bursting: a theoretical investigation.Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion.A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cellsAccounting for near-normal glucose sensitivity in Kir6.2[AAA] transgenic mice.Contributions of mathematical modeling of beta cells to the understanding of beta-cell oscillations and insulin secretionMathematical models for insulin secretion in pancreatic β-cells.Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics.Mathematical models of electrical activity of the pancreatic β-cell: a physiological review.Toward integration of biological and physiological functions at multiple levels.
P2860
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P2860
Modeling of Ca2+ flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Modeling of Ca2+ flux in pancr ...... rane and intracellular stores.
@en
Modeling of Ca2+ flux in pancr ...... rane and intracellular stores.
@nl
type
label
Modeling of Ca2+ flux in pancr ...... rane and intracellular stores.
@en
Modeling of Ca2+ flux in pancr ...... rane and intracellular stores.
@nl
prefLabel
Modeling of Ca2+ flux in pancr ...... rane and intracellular stores.
@en
Modeling of Ca2+ flux in pancr ...... rane and intracellular stores.
@nl
P2093
P2860
P1476
Modeling of Ca2+ flux in pancr ...... rane and intracellular stores.
@en
P2093
Leonid E Fridlyand
Louis H Philipson
Natalia Tamarina
P2860
P304
P356
10.1152/AJPENDO.00194.2002
P577
2003-03-18T00:00:00Z