NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. - Wikidata - wikimedia - TriplyDB

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

http://www.wikidata.org/entity/Q44436565

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Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway Up on the tightrope: natural killer cell activation and inhibition Complexity and Diversity of the NKR-P1:Clr (Klrb1:Clec2) Recognition Systems Important roles for gamma interferon and NKG2D in gammadelta T-cell-induced demyelination in T-cell receptor beta-deficient mice infected with a coronavirus Costimulation of dendritic epidermal gammadelta T cells by a new NKG2D ligand expressed specifically in the skin Recognition of tumors by the innate immune system and natural killer cells.NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production.Functions of skin-resident γδ T cells DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production.Natural killer cells in patients with severe chronic fatigue syndrome.Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice Inositol phospholipid signaling and the biology of natural killer cells.Targeting Syk as a treatment for allergic and autoimmune disorders.Activation of natural killer cells: underlying molecular mechanisms revealed.PI3Ks in lymphocyte signaling and development Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion Multiplicity and plasticity of natural killer cell signaling pathways.Interplay of natural killer cells and their receptors with the adaptive immune response.Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma Differential effects of stimulatory factors on natural killer cell activities of young and aged mice.Role of ITAM-containing adapter proteins and their receptors in the immune system and bone.Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells.Natural killer lytic-associated molecule plays a role in controlling tumor dissemination and metastasis.JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity Signaling for synergistic activation of natural killer cells.Activation, coactivation, and costimulation of resting human natural killer cells Dissecting natural killer cell activation pathways through analysis of genetic mutations in human and mouse.Activation and self-tolerance of natural killer cells.The SYK tyrosine kinase: a crucial player in diverse biological functions.The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation NK cell-activating receptors require PKC-theta for sustained signaling, transcriptional activation, and IFN-gamma secretion.p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.

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P2860

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

http://www.wikidata.org/entity/Q44436565

description

2003 nî lūn-bûn

@nan

2003年の論文

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2003年学术文章

@wuu

2003年学术文章

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2003年学术文章

@zh-cn

2003年学术文章

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2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

2003年學術文章

@zh-hant

name

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

@en

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

@nl

type

label

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

@en

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

@nl

prefLabel

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

@en

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

@nl

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P1433

Nature Immunology

P1476

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases

@en

P2093

Edina Schweighoffer

http://www.w3.org/2001/XMLSchema#string

Jessica A Hamerman

http://www.w3.org/2001/XMLSchema#string

Kouetsu Ogasawara

http://www.w3.org/2001/XMLSchema#string

Lewis L Lanier

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Simona Zompi

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P2860

Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA

An activating immunoreceptor complex formed by NKG2D and DAP10

Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells

ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells

NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway

2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways

NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation

Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D

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565-572

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10.1038/NI930

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P433

6

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4

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James P Di Santo

Francesco Colucci

Victor Tybulewicz

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2003-05-11T00:00:00Z

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10764878

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12740576

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P921