Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.
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Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and CancerBile acid metabolism and signalingFXR signaling in the enterohepatic systemBile acid signaling in metabolic disease and drug therapyFarnesoid X receptor: from medicinal chemistry to clinical applicationsFXR-mediated regulation of eNOS expression in vascular endothelial cellsMetabolic Profile of Obeticholic Acid and Endogenous Bile Acids in Rats with Decompensated Liver CirrhosisMedical treatment of cholestatic liver diseases: From pathobiology to pharmacological targets.Farnesoid X receptor activation prevents the development of vascular calcification in ApoE-/- mice with chronic kidney disease.The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid.Recent advances in the development of farnesoid X receptor agonistsDeciphering the nuclear bile acid receptor FXR paradigm.Current research on the treatment of primary sclerosing cholangitis.Steroids: partial synthesis in medicinal chemistry.Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis.Exploitation of bile acid transport systems in prodrug design.Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules.Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge.New generation lipid emulsions prevent PNALD in chronic parenterally fed preterm pigs.Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.Digestive physiology of the pig symposium: intestinal bile acid sensing is linked to key endocrine and metabolic signaling pathways.Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome.Nuclear receptors in bile acid metabolismFarnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?FXR agonists as therapeutic agents for non-alcoholic fatty liver disease.New and Investigational Agents for Irritable Bowel Syndrome.Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis.FXR Agonists: From Bench to Bedside, a Guide for Clinicians.Novel biotinylated bile acid amphiphiles: micellar aggregates formation and interaction with hepatocytes.Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators.The FXR Agonist, Obeticholic Acid, Suppresses HCC Proliferation & Metastasis: Role of IL-6/STAT3 Signalling Pathway.Treatment options for alcoholic and non-alcoholic fatty liver disease: A review.Synthesis and quantitative structure-property relationships of side chain-modified hyodeoxycholic acid derivatives.Antiatherosclerotic effect of farnesoid X receptor.Synthesis and Biological Evaluation of a Series of Bile Acid Derivatives as FXR Agonists for Treatment of NASH.Bile acid metabolism in liver pathobiology.Clinical and metabolic effects associated with weight changes and obeticholic acid in non-alcoholic steatohepatitis.Fast chromatographic determination of the bile salt critical micellar concentration.Bile acid metabolism and signaling in liver disease and therapy
P2860
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P2860
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Bile acid derivatives as ligan ...... gues of chenodeoxycholic acid.
@en
Bile acid derivatives as ligan ...... gues of chenodeoxycholic acid.
@nl
type
label
Bile acid derivatives as ligan ...... gues of chenodeoxycholic acid.
@en
Bile acid derivatives as ligan ...... gues of chenodeoxycholic acid.
@nl
prefLabel
Bile acid derivatives as ligan ...... gues of chenodeoxycholic acid.
@en
Bile acid derivatives as ligan ...... gues of chenodeoxycholic acid.
@nl
P2093
P356
P1476
Bile acid derivatives as ligan ...... gues of chenodeoxycholic acid.
@en
P2093
Antimo Gioiello
Antonio Entrena
Bahman M Sadeghpour
Carlo Clerici
Gabriele Costantino
Roberto Pellicciari
Stefano Fiorucci
Timothy M Willson
P304
P356
10.1021/JM049904B
P407
P577
2004-08-01T00:00:00Z