The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.
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Role of Nuclear Receptors in Central Nervous System Development and Associated DiseasesPregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator InteractionsModeling of rifampicin-induced CYP3A4 activation dynamics for the prediction of clinical drug-drug interactions from in vitro dataRifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human HepatocytesRole of nuclear receptor SHP in metabolism and cancer.Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner.A mechanism-based pharmacokinetic/pharmacodynamic model for CYP3A1/2 induction by dexamethasone in ratsOrphan nuclear receptor small heterodimer partner inhibits angiotensin II- stimulated PAI-1 expression in vascular smooth muscle cells.Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.The HR97 (NR1L) group of nuclear receptors: a new group of nuclear receptors discovered in Daphnia species.HNF4α--role in drug metabolism and potential drug target?Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium FerulateRifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 geneDaphnia HR96 is a promiscuous xenobiotic and endobiotic nuclear receptorA pleiotropic role for the orphan nuclear receptor small heterodimer partner in lipid homeostasis and metabolic pathways.New Insights into Orphan Nuclear Receptor SHP in Liver CancerSynthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.Crosstalk between xenobiotics metabolism and circadian clock.Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- micePhosphorylation and protein-protein interactions in PXR-mediated CYP3A repression.The orphan nuclear receptor SHP attenuates renal fibrosis.The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.Targeting orphan nuclear receptor SHP in the treatment of metabolic diseases.The impact of cholesterol and its metabolites on drug metabolism.Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver.Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily.Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine.U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene.Feed-forward regulation of bile acid detoxification by CYP3A4: studies in humanized transgenic mice.Loss of small heterodimer partner expression in the liver protects against dyslipidemia.Orphan nuclear receptor small heterodimer partner inhibits transforming growth factor-beta signaling by repressing SMAD3 transactivation.
P2860
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P2860
The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
The small heterodimer partner ...... its transcriptional activity.
@en
The small heterodimer partner ...... its transcriptional activity.
@nl
type
label
The small heterodimer partner ...... its transcriptional activity.
@en
The small heterodimer partner ...... its transcriptional activity.
@nl
prefLabel
The small heterodimer partner ...... its transcriptional activity.
@en
The small heterodimer partner ...... its transcriptional activity.
@nl
P2093
P356
P1476
The small heterodimer partner ...... s its transcriptional activity
@en
P2093
Frederic Lasserre
Jean Claude Ourlin
Jean Michel Fabre
Marie-Jose Vilarem
Patrick Maurel
Thierry Pineau
P304
P356
10.1210/ME.2002-0383
P577
2003-06-12T00:00:00Z