about
Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of LckDexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoterDehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptorCYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα sitePregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expressionPathophysiological factors affecting CAR gene expression.Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response.Pregnane X-receptor promotes stem cell-mediated colon cancer relapseExpression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer.The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism.Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells.Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes.Integrated comparison of drug-related and drug-induced ultra performance liquid chromatography/mass spectrometry metabonomic profiles using human hepatocyte cultures.N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system.Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture.A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte.Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors.Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes.Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors.Metabonomic studies on human hepatocyte in primary culture.Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3).Response to Zhou et al. Osteomalacia is a frequent complication resulting from long-term therapy with drugs such as phenytoin, carbamazepine, and phenobarbital.The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes.[Drug-induced osteomalacia : possible role of PXR, a receptor involved in detoxification].Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor.Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Jean Marc Pascussi
@ast
Jean Marc Pascussi
@en
Jean Marc Pascussi
@es
Jean Marc Pascussi
@nl
type
label
Jean Marc Pascussi
@ast
Jean Marc Pascussi
@en
Jean Marc Pascussi
@es
Jean Marc Pascussi
@nl
prefLabel
Jean Marc Pascussi
@ast
Jean Marc Pascussi
@en
Jean Marc Pascussi
@es
Jean Marc Pascussi
@nl
P214
P269
P106
P214
P269
P31
P496
0000-0002-5168-5383
P7859
viaf-209202701