Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile.
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Diversity of microbial sialic acid metabolismSialidases from gut bacteria: a mini-reviewStructure of Kre2p/Mnt1p: a yeast alpha1,2-mannosyltransferase involved in mannoprotein biosynthesisStructural basis for cyclophellitol inhibition of a beta-glucosidaseThe Structure of Clostridium perfringens NanI Sialidase and Its Catalytic IntermediatesStructural and Kinetic Analysis of Bacillus subtilis N-Acetylglucosaminidase Reveals a Unique Asp-His Dyad MechanismTrypanosoma cruzi trans-Sialidase in Complex with a Neutralizing Antibody: Structure/Function Studies towards the Rational Design of InhibitorsMechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activityTuning mechanism-based inactivators of neuraminidases: mechanistic and structural insightsContribution of Shape and Charge to the Inhibition of a Family GH99 endo-α-1,2-MannanaseMechanistic study of CMP-Neu5Ac hydrolysis by α2,3-sialyltransferase from Pasteurella dagmatis.Contribution of the active site aspartic acid to catalysis in the bacterial neuraminidase from Micromonospora viridifaciens.Unraveling the differences of the hydrolytic activity of Trypanosoma cruzi trans-sialidase and Trypanosoma rangeli sialidase: a quantum mechanics-molecular mechanics modeling study.Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside librariesDevelopment of inhibitors as research tools for carbohydrate-processing enzymes.Proton transfer facilitated by ligand binding. An energetic analysis of the catalytic mechanism of Trypanosoma cruzi trans-sialidase.Galactosyl-lactose sialylation using Trypanosoma cruzi trans-sialidase as the biocatalyst and bovine κ-casein-derived glycomacropeptide as the donor substrateSialic acid: a sweet swing between mammalian host and Trypanosoma cruziSialic acid metabolism and sialyltransferases: natural functions and applications.Cell-permeable probe for identification and imaging of sialidasesInsights into the activity and specificity of Trypanosoma cruzi trans-sialidase from molecular dynamics simulationsCovalent inhibitors of glycosidases and their applications in biochemistry and biology.Free energy study of the catalytic mechanism of Trypanosoma cruzi trans-sialidase. From the Michaelis complex to the covalent intermediate.Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host.Glycosidase inhibition: assessing mimicry of the transition state.Irreversible inhibitors and activity-based probes as research tools in chemical glycobiology.The chemistry and biology of trypanosomal trans-sialidases: virulence factors in Chagas disease and sleeping sickness.Trypanosoma cruzi trans-sialidase as a drug target against Chagas disease (American trypanosomiasis).Sialylation of lactosyl lipids in membrane microdomains by T. cruzi trans-sialidase.pKa cycling of the general acid/base in glycoside hydrolase families 33 and 34.Synthesis of Neu5Ac oligosaccharides and analogues by transglycosylation and their binding properties as ligands to MAG.Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue.Enzymatically inactive trans-sialidase from Trypanosoma cruzi binds sialyl and beta-galactopyranosyl residues in a sequential ordered mechanism.Glycosynthesis in a waterworld: new insight into the molecular basis of transglycosylation in retaining glycoside hydrolases.The trans-sialidase, the major Trypanosoma cruzi virulence factor: Three decades of studies.Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015).Recent developments in trans-sialidase inhibitors of Trypanosoma cruzi.Synthesis and evaluation of influenza A viral neuraminidase candidate inhibitors based on a bicyclo[3.1.0]hexane scaffold.Use of Fluorinated Functionality in Enzyme Inhibitor Development: Mechanistic and Analytical AdvantagesStreptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR.
P2860
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P2860
Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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name
Trypanosoma cruzi trans-sialid ...... is the catalytic nucleophile.
@en
Trypanosoma cruzi trans-sialid ...... is the catalytic nucleophile.
@nl
type
label
Trypanosoma cruzi trans-sialid ...... is the catalytic nucleophile.
@en
Trypanosoma cruzi trans-sialid ...... is the catalytic nucleophile.
@nl
prefLabel
Trypanosoma cruzi trans-sialid ...... is the catalytic nucleophile.
@en
Trypanosoma cruzi trans-sialid ...... is the catalytic nucleophile.
@nl
P2093
P50
P356
P1476
Trypanosoma cruzi trans-sialid ...... is the catalytic nucleophile.
@en
P2093
Alberto C Frasch
Iben Damager
Maria L Amaya
Stephen G Withers
P304
P356
10.1021/JA0344967
P407
P577
2003-06-01T00:00:00Z