Establishing a link between amino acid sequences and self-associating and viscoelastic behavior of two closely related monoclonal antibodies.
about
Effects of localized interactions and surface properties on stability of protein-based therapeutics.In silico selection of therapeutic antibodies for development: viscosity, clearance, and chemical stability.Isolation and optimization for affinity and biophysical characteristics of anti-CCL17 antibodies from the VH1-69 germline gene.Parallel temperature-dependent microrheological measurements in a microfluidic chip.Molecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product developmentAssessment and significance of protein-protein interactions during development of protein biopharmaceuticals.Challenges in Determining Intrinsic Viscosity Under Low Ionic Strength Solution Conditions.Monoclonal antibodies: formulations of marketed products and recent advances in novel delivery system.Mechanisms of self-association of a human monoclonal antibody CNTO607.Resolving self-association of a therapeutic antibody by formulation optimization and molecular approaches.Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineeringCharge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity.Weak interactions govern the viscosity of concentrated antibody solutions: high-throughput analysis using the diffusion interaction parameterHydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody.Rational design of viscosity reducing mutants of a monoclonal antibody: hydrophobic versus electrostatic inter-molecular interactions.Effects of ionic strength and sugars on the aggregation propensity of monoclonal antibodies: influence of colloidal and conformational stabilities.Viscosity Control of Protein Solution by Small Solutes: A Review.Quantitative Correlation between Viscosity of Concentrated MAb Solutions and Particle Size Parameters Obtained from Small-Angle X-ray Scattering.Intermolecular interactions involving an acidic patch on immunoglobulin variable domain and the γ2 constant region mediate crystalline inclusion body formation in the endoplasmic reticulum.Concentration dependent viscosity of monoclonal antibody solutions: explaining experimental behavior in terms of molecular properties.Discovery of highly soluble antibodies prior to purification using affinity-capture self-interaction nanoparticle spectroscopy.Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold.A comparative study of monoclonal antibodies. 1. Phase behavior and protein-protein interactions.Dipole-dipole interaction in antibody solutions: correlation with viscosity behavior at high concentration
P2860
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P2860
Establishing a link between amino acid sequences and self-associating and viscoelastic behavior of two closely related monoclonal antibodies.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
Establishing a link between am ...... related monoclonal antibodies.
@en
Establishing a link between am ...... related monoclonal antibodies.
@nl
type
label
Establishing a link between am ...... related monoclonal antibodies.
@en
Establishing a link between am ...... related monoclonal antibodies.
@nl
prefLabel
Establishing a link between am ...... related monoclonal antibodies.
@en
Establishing a link between am ...... related monoclonal antibodies.
@nl
P2093
P2860
P1476
Establishing a link between am ...... related monoclonal antibodies.
@en
P2093
Alavattam Sreedhara
Devendra S Kalonia
Henry Lowman
Samantha Lien
Sandeep Yadav
Sonoko Kanai
Steven J Shire
P2860
P304
P356
10.1007/S11095-011-0410-0
P577
2011-04-06T00:00:00Z