Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. - Wikidata - wikimedia - TriplyDB

Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1.

Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1.

http://www.wikidata.org/entity/Q44534322

about

The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport.The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production CD74 interacts with APP and suppresses the production of Abeta The amyloid-beta precursor protein: integrating structure with biological function A unique set of SH3-SH3 interactions controls IB1 homodimerization.Control of a kinesin-cargo linkage mechanism by JNK pathway kinases Calsyntenin-1 docks vesicular cargo to kinesin-1 Role of HIV in amyloid metabolism Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells Proteolytic processing of Alzheimer's β-amyloid precursor protein Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1 Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis Axonal transport and neurodegenerative disease: can we see the elephant?APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila.Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles.Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport.Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production.Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport The beta-amyloid precursor protein controls a store-operated Ca2+ entry in cortical neurons.A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance.Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss.The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain.A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.Syd/JIP3 and JNK signaling are required for myonuclear positioning and muscle function.Amyloid-β precursor protein: Multiple fragments, numerous transport routes and mechanisms N-terminal kinesins: many and various.Unconventional functions of microtubule motors.Molecular motors and mechanisms of directional transport in neurons.The axonal transport of mitochondria.Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?Structural and biomechanical basis of mitochondrial movement in eukaryotic cells The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.

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P2860

Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1.

http://www.wikidata.org/entity/Q44534322

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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name

Amyloid beta protein precursor ...... ein JNK-interacting protein 1.

@en

Amyloid beta protein precursor ...... ein JNK-interacting protein 1.

@nl

type

label

Amyloid beta protein precursor ...... ein JNK-interacting protein 1.

@en

Amyloid beta protein precursor ...... ein JNK-interacting protein 1.

@nl

prefLabel

Amyloid beta protein precursor ...... ein JNK-interacting protein 1.

@en

Amyloid beta protein precursor ...... ein JNK-interacting protein 1.

@nl

P1433

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P1433

Journal of Biological Chemistry

P1476

Amyloid beta protein precursor ...... ein JNK-interacting protein 1.

@en

P2093

Luciano D'Adamio

http://www.w3.org/2001/XMLSchema#string

Shuji Matsuda

http://www.w3.org/2001/XMLSchema#string

Yukiko Matsuda

http://www.w3.org/2001/XMLSchema#string

P2860

The JIP group of mitogen-activated protein kinase scaffold proteins

JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway

Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3

Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

P304

38601-38606

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scholarly article

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10.1074/JBC.M304379200

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40

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278

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2003-07-31T00:00:00Z

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12893827

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