Effect of the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin on proofreading by Escherichia coli DNA polymerase I (Klenow fragment) in different sequence contexts.
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Crystal Structure of a Replicative DNA Polymerase Bound to the Oxidized Guanine Lesion Guanidinohydantoin ,Substitution of Ala for Tyr567 in RB69 DNA Polymerase Allows dAMP and dGMP To Be Inserted opposite Guanidinohydantoin,Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating PositionThe mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivoAbsolute configurations of DNA lesions determined by comparisons of experimental ECD and ORD spectra with DFT calculationsBase-excision repair of oxidative DNA damageThermodynamic profiles and nuclear magnetic resonance studies of oligonucleotide duplexes containing single diastereomeric spiroiminodihydantoin lesions.Absolute configurations of spiroiminodihydantoin and allantoin stereoisomers: comparison of computed and measured electronic circular dichroism spectra.Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts.Spirodi(iminohydantoin) products from oxidation of 2'-deoxyguanosine in the presence of NH4Cl in nucleoside and oligodeoxynucleotide contexts.pH-Dependent Equilibrium between 5-Guanidinohydantoin and Iminoallantoin Affects Nucleotide Insertion Opposite the DNA Lesion.Effect of Base-Pairing Partner on the Thermodynamic Stability of the Diastereomeric Spiroiminodihydantoin Lesion.Guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair.In vitro ligation of oligodeoxynucleotides containing C8-oxidized purine lesions using bacteriophage T4 DNA ligase.Unusual structural features of hydantoin lesions translate into efficient recognition by Escherichia coli FpgNeil3, the final frontier for the DNA glycosylases that recognize oxidative damage.Chemical and electrochemical oxidation of C8-arylamine adducts of 2'-deoxyguanosineSuperior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair.Endonuclease and Exonuclease Activities on Oligodeoxynucleotides Containing Spiroiminodihydantoin Depend on the Sequence Context and the Lesion Stereochemistry.Chemical and biological consequences of oxidatively damaged guanine in DNA.Reverse Transcription Past Products of Guanine Oxidation in RNA Leads to Insertion of A and C opposite 8-Oxo-7,8-dihydroguanine and A and G opposite 5-Guanidinohydantoin and Spiroiminodihydantoin Diastereomers.The Nonbulky DNA Lesions Spiroiminodihydantoin and 5-Guanidinohydantoin Significantly Block Human RNA Polymerase II Elongation in Vitro.Formation and processing of DNA damage substrates for the hNEIL enzymes.Synthesis and characterization of the oxidized dGTP lesions spiroiminodihydantoin-2'-deoxynucleoside-5'- triphosphate and guanidinohydantoin-2'-deoxynucleoside-5'- triphosphate.Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairingSequencing the Mouse Genome for the Oxidatively Modified Base 8-Oxo-7,8-dihydroguanine by OG-Seq.Conformational stabilities of iminoallantoin and its base pairs in DNA: implications for mutagenicity.
P2860
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P2860
Effect of the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin on proofreading by Escherichia coli DNA polymerase I (Klenow fragment) in different sequence contexts.
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name
Effect of the oxidized guanosi ...... n different sequence contexts.
@en
Effect of the oxidized guanosi ...... herichia coli DNA polymerase I
@nl
type
label
Effect of the oxidized guanosi ...... n different sequence contexts.
@en
Effect of the oxidized guanosi ...... herichia coli DNA polymerase I
@nl
prefLabel
Effect of the oxidized guanosi ...... n different sequence contexts.
@en
Effect of the oxidized guanosi ...... herichia coli DNA polymerase I
@nl
P356
P1433
P1476
Effect of the oxidized guanosi ...... n different sequence contexts.
@en
P2093
Cynthia J Burrows
Olga Kornyushyna
P304
13008-13018
P356
10.1021/BI0350755
P407
P577
2003-11-01T00:00:00Z