Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease. - Wikidata - wikimedia - TriplyDB

Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease.

Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease.

http://www.wikidata.org/entity/Q44645467

about

GSK-3β: A Bifunctional Role in Cell Death Pathways The pathobiology of splicing SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A GSK-3: Functional Insights from Cell Biology and Animal Models.Alternative splicing of exon 10 in the tau gene as a target for treatment of tauopathies.Bioactive marine drugs and marine biomaterials for brain diseases Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo Quantitative phosphoproteomics reveals link between Helicobacter pylori infection and RNA splicing modulation in host cells.Vitamin A metabolite, all-trans-retinoic acid, mediates alternative splicing of protein kinase C deltaVIII (PKCdeltaVIII) isoform via splicing factor SC35.Structural genomics analysis of alternative splicing and application to isoform structure modeling.Regulation of alternative splicing by reversible protein phosphorylation.Splicing factor SC35 promotes tau expression through stabilization of its mRNA.GSK-3 in Neurodegenerative Diseases.What Are the bona fide GSK3 Substrates?Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease.Advances in tau-based drug discovery.SC35 promotes splicing of the C5-V6-C6 isoform of CD44 pre-mRNA MicroRNAs and the Regulation of Tau Metabolism The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus.Structural determinants for alternative splicing regulation of the MAPT pre-mRNA HIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase.Tau exon 10 alternative splicing and tauopathies Knock-out and transgenic mouse models of tauopathies.Alternative splicing and tumor progression.Alternative splicing and disease.Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells.Degrade, move, regroup: signaling control of splicing proteins.Functional implications of glycogen synthase kinase-3-mediated tau phosphorylation Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles Regulation of alternative splicing of tau exon 10.The Role of Glycogen Synthase Kinase 3 Beta in Neuroinflammation and Pain.C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A.Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3β.Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome Nuclear speckles: molecular organization, biological function and role in disease.Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3 Do astrocytes collaborate with neurons in spreading the "infectious" aβ and Tau drivers of Alzheimer's disease?Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing.

P2860

Q21285144-2547B7C8-E2B3-4AD4-878A-DF30988A42CD Q24634680-8517A700-2408-4E31-8733-70DDDD5C5BC1 Q24670290-93E327A5-4B31-4CB4-AB58-E1AA3F51DDB1 Q24685475-EC534A59-7759-43E0-A180-4DC764865995 Q28592850-162F8222-000D-4D87-98CA-6184449FB485 Q30472813-F00D3ED6-9CB8-4FDA-9C8D-86AF6548E4DC Q33393896-D7FFC7CC-6084-469B-80C2-39D774614CB1 Q33736687-330C447E-522F-4B9B-8840-D49925DF058E Q33771431-9B117401-E9BB-4EBD-89D7-3C13DDE5932F Q33946885-E54F785C-AD6A-4224-A418-F2E6EBF1EF24 Q34074258-C06DE860-E374-4548-9E59-7F27EC43C35D Q34244987-F216EA16-8E93-4369-B64F-2FCB49DD9AAB Q34585110-953D6175-8EEA-43AE-ABB6-8DE805075EC4 Q34764464-28AAED26-2FF2-44F9-96FD-3FE4CB18E25F Q35001040-78D381E6-4AB8-4F92-941C-7CD04638D9A6 Q35001234-E164F756-F6DC-4C7F-9C76-8D18656FD389 Q35035648-01382AB4-290F-4636-BEEC-0AB8CD5CABF5 Q35321539-4C84F66B-D1A2-49DA-9E9F-2CFBC329F469 Q35926348-1DE91F75-C15B-46B8-89D7-D17B5923C2A6 Q36031159-8951C1D1-1572-4CFB-BCDC-359E12E61A4E Q36161960-415CCFEC-3C82-4F15-9FFB-59AEDD63706F Q36191411-C001C205-152F-4E62-AA67-B2165A783B9E Q36407266-E7689ECB-7987-4539-836E-D896DFD1BBF3 Q36789895-5C9CC78E-65F6-4B96-88DA-E6C67FF421B6 Q36859244-261A0D14-402B-4399-A14B-3F17280A93A1 Q37222930-A5F9B572-12ED-440B-8E6F-6B7BAF79FF07 Q37320845-B9C2DC53-03F8-4C3C-B632-47D545693DAA Q37661658-B3B41FC3-1495-4BA5-BD11-23AD49AFF734 Q37877384-59B5F643-0B83-4F7B-B1BB-74E99859296E Q37903257-C472FB7B-3FAD-4EA9-85A9-817F1FADDFF7 Q38177975-625E28BD-2DE5-4823-A0BF-1DAB41AD4064 Q38195811-B8182D15-672E-40C7-A101-7A61F6F14B15 Q38259593-2ACA63BD-D6D9-4A07-8892-A13239088602 Q38713373-EAA259E8-AA27-4EEC-8F05-B3B207ACA088 Q38859228-E3DE6DF6-692F-4002-B53A-74CFD3786271 Q39956895-E9B8A849-D528-45FB-BBF0-CBEB663A76F6 Q41924562-67C9FAC9-CA20-42D8-A733-19EFA4603AF7 Q42102101-D6231701-9E18-41C0-935B-0C18FEFDD0C5 Q42218999-12B9C1B4-31E1-47FF-9212-9E62A6CAD07F Q42777723-F0BFC7F2-71DF-4FF7-A97B-429181192912

P2860

Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease.

http://www.wikidata.org/entity/Q44645467

description

2003 nî lūn-bûn

@nan

2003年の論文

@ja

2003年学术文章

@wuu

2003年学术文章

@zh

2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

2003年學術文章

@zh-hant

name

Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.

@en

Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.

@nl

type

label

Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.

@en

Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.

@nl

prefLabel

Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.

@en

Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.

@nl

P1433

Q44645467-818D1ECD-9956-4449-9476-237665C601E2

P1476

Q44645467-C32BF002-28BE-47F8-8E34-D3C093545E61

P2093

Q44645467-14757971-46BE-4F84-9964-22B2B010CA47

Q44645467-1E48EE43-826C-4A78-A79B-62BE0D28C3CD

Q44645467-99FD504B-3A74-43C0-927B-8E046A324D52

Q44645467-C1ED9BFC-976E-4E08-892A-79EE1A69D25D

Q44645467-CB9D5018-175A-4B94-98E9-EC38EA610BED

P2860

Q44645467-0A2134F2-FC8D-4642-BF08-6BE3ACAB5E34

Q44645467-164A5411-310E-4A1C-BDBC-72FEE771B2E2

Q44645467-165F155F-5EE6-415B-A1B1-6C15EFEC972B

Q44645467-195B8238-F1C5-4FB3-B8CA-11624787E7A2

Q44645467-19D280DA-17B4-40F8-A78D-E571076A32DB

Q44645467-1E03BD1F-BC37-4BB7-AA3C-526A8F11FE75

Q44645467-1E7D7DCB-8E5C-4520-9E5A-4C42C8EB140F

Q44645467-2878B294-6772-4CE5-9588-4DDC2FC5103E

Q44645467-2F5688AF-E10A-4AF4-BCCA-5B8524DFD42E

Q44645467-341D7A69-BF90-4708-8BF6-A62F52B7178E

P304

Q44645467-FF5DD4A2-A668-4101-B63B-F3C3A53B3515

P31

Q44645467-B9C42853-010A-4C3E-B9F9-07637E5AE165

P356

Q44645467-C748A2F5-7672-4E6F-9024-0442F6123247

P407

Q44645467-323ED866-41E1-4172-BCB0-6DC7C76B0E4A

P433

Q44645467-5AF176D6-7E59-47FD-AA55-E0C46A751AD2

P478

Q44645467-EC62F3B1-C8B2-4B1B-91CB-0A0883D6084F

P50

Q44645467-C3ACB2BF-017E-465F-B5F5-9D30ED74492F

P577

Q44645467-CBF79310-7D9D-40D7-9BF9-C4D9C3B5299B

P698

Q44645467-32DBF79A-B03B-4CB6-82E9-B06CC1A50984

P921

Q44645467-EBEC6D65-FAAF-40D2-BDC4-DD57B372B0CD

P356

P1433

Journal of Biological Chemistry

P1476

Glycogen synthase kinase-3 pla ...... tions for Alzheimer's disease.

@en

P2093

Ana M Mata

http://www.w3.org/2001/XMLSchema#string

Félix Hernández

http://www.w3.org/2001/XMLSchema#string

Jesús Avila

http://www.w3.org/2001/XMLSchema#string

Mar Pérez

http://www.w3.org/2001/XMLSchema#string

Ratan Bhat

http://www.w3.org/2001/XMLSchema#string

P2860

Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

Sorting out the complexity of SR protein functions

A molecular mechanism for the effect of lithium on development

Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17

Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

P304

3801-3806

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M311512200

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

279

http://www.w3.org/2001/XMLSchema#string

P50

P577

2003-11-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

14602710

http://www.w3.org/2001/XMLSchema#string

P921

Alzheimer's disease