Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release. - Wikidata - wikimedia - TriplyDB

Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release.

Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release.

http://www.wikidata.org/entity/Q44793030

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Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats New Therapeutic Options for Autism Spectrum Disorder: Experimental Evidences Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity Elucidating the role of neurotensin in the pathophysiology and management of major mental disorders.Allosteric modulation of metabotropic glutamate receptors.Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia?The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse.The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects.β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X.Cue-conditioned alcohol seeking in rats following abstinence: involvement of metabotropic glutamate 5 receptors.mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm.NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons.Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.Functional interaction of mGlu5 and NMDA receptors in aversive learning in rats.mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway.Effects of the nitric oxide synthase inhibitor L-NAME on recognition and spatial memory deficits produced by different NMDA receptor antagonists in the rat.Pharmacological enhancement of memory and executive functioning in laboratory animals.Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in mice mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration.Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys.An N-methyl-D-aspartate receptor agonist facilitates sleep-independent synaptic plasticity associated with working memory capacity enhancement Therapeutic potential of mGluR5 targeting in Alzheimer's disease The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task.Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73 Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator.Therapeutic potential of metabotropic glutamate receptor modulators.Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade.Translational Concepts of mGluR5 in Synaptic Diseases of the Brain Disruption of prefrontal cortex large scale neuronal activity by different classes of psychotomimetic drugs Susceptibility of the adolescent brain to cannabinoids: long-term hippocampal effects and relevance to schizophrenia.

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Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release.

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P2860

Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer

NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development

Genes for schizophrenia? Recent findings and their pathophysiological implications

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

Regulation of neurotransmitter release by metabotropic glutamate receptors

Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses

Recent advances in the phencyclidine model of schizophrenia

Pharmacology and functions of metabotropic glutamate receptors

Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose.

Group I metabotropic glutamate receptors: implications for brain diseases.

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