Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm.
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Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor functionNeural structures underlying set-shifting: roles of medial prefrontal cortex and anterior cingulate cortexEmerging approaches for treatment of schizophrenia: modulation of glutamatergic signalingBiased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR CurrentsFast and slow transitions in frontal ensemble activity during flexible sensorimotor behavior.Targeting glutamate synapses in schizophreniaSetdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B.Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5Methamphetamine self-administration produces attentional set-shifting deficits and alters prefrontal cortical neurophysiology in rats.Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood.Clinical physiology and mechanism of dizocilpine (MK-801): electron transfer, radicals, redox metabolites and bioactivitymGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learningCognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.Disruption of performance in the five-choice serial reaction time task induced by administration of N-methyl-D-aspartate receptor antagonists: relevance to cognitive dysfunction in schizophreniaSerum glutamine, set-shifting ability and anorexia nervosa.The NMDA receptor as a target for cognitive enhancementDevelopment of allosteric modulators of GPCRs for treatment of CNS disordersOpportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Functional interaction of mGlu5 and NMDA receptors in aversive learning in rats.Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in micemGluR5 positive allosteric modulation and its effects on MK-801 induced set-shifting impairments in a rat operant delayed matching/non-matching-to-sample taskCognitive enhancers for facilitating drug cue extinction: insights from animal models.Therapeutic potential of metabotropic glutamate receptor modulators.The mGluR5 Positive Allosteric Modulator CDPPB Does Not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in RatsmGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal CortexProgress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).Anxiety Evokes Hypofrontality and Disrupts Rule-Relevant Encoding by Dorsomedial Prefrontal Cortex Neurons.Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine.Distinct manifestations of executive dysfunction in aged rats.Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.Glutamate Neurotransmission in Psychotic Disorders and Substance Abuse.Metabotropic glutamate receptors: physiology, pharmacology, and disease.Metabotropic glutamate receptors as therapeutic targets for schizophrenia.Leading compounds for the validation of animal models of psychopathology.Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research.Neurophysiology of rule switching in the corticostriatal circuit.
P2860
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P2860
Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Interaction of N-methyl-D-aspa ...... el operant set-shift paradigm.
@ast
Interaction of N-methyl-D-aspa ...... el operant set-shift paradigm.
@en
Interaction of N-methyl-D-aspa ...... el operant set-shift paradigm.
@nl
type
label
Interaction of N-methyl-D-aspa ...... el operant set-shift paradigm.
@ast
Interaction of N-methyl-D-aspa ...... el operant set-shift paradigm.
@en
Interaction of N-methyl-D-aspa ...... el operant set-shift paradigm.
@nl
prefLabel
Interaction of N-methyl-D-aspa ...... el operant set-shift paradigm.
@ast
Interaction of N-methyl-D-aspa ...... el operant set-shift paradigm.
@en
Interaction of N-methyl-D-aspa ...... el operant set-shift paradigm.
@nl
P2860
P1476
Interaction of N-methyl-D-aspa ...... el operant set-shift paradigm.
@en
P2093
Justin M Darrah
Mark R Stefani
P2860
P304
P356
10.1097/FBP.0B013E3282FEB0AC
P577
2008-05-01T00:00:00Z