Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells.
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Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosisGuards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetesHearts from mice fed a non-obesogenic high-fat diet exhibit changes in their oxidative state, calcium and mitochondria in parallel with increased susceptibility to reperfusion injuryPalmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms.Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles.A critical role for human caspase-4 in endotoxin sensitivity.Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic β-cellsA role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic ß-cells.Rab27a: a new face in beta cell metabolism-secretion coupling.Optogenetic control of insulin secretion in intact pancreatic islets with β-cell-specific expression of Channelrhodopsin-2.Glucose-sensing mechanisms in pancreatic beta-cells.Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagonDifferential modulation of L-type calcium channel subunits by oleate.Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin networkRegulation of voltage-gated Ca2+ channels by lipids.The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?Regulation of calcium in pancreatic α- and β-cells in health and disease.Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion.Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells.Evidence for the involvement of GPR40 and NADPH oxidase in palmitic acid-induced superoxide production and insulin secretion.Escherichia coli outer membrane vesicles can contribute to sepsis induced cardiac dysfunction.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY.Mathematical modelling of local calcium and regulated exocytosis during inhibition and stimulation of glucagon secretion from pancreatic alpha-cells.Modulation of large dense core vesicle insulin content mediates rhythmic hormone release from pancreatic beta cells over the 24h cycle.A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1.NAD(P)H oxidase participates in the palmitate-induced superoxide production and insulin secretion by rat pancreatic islets.
P2860
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P2860
Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells.
description
2004 nî lūn-bûn
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2004年の論文
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name
Palmitate increases L-type Ca2 ...... n mouse pancreatic beta-cells.
@en
Palmitate increases L-type Ca2 ...... n mouse pancreatic beta-cells.
@nl
type
label
Palmitate increases L-type Ca2 ...... n mouse pancreatic beta-cells.
@en
Palmitate increases L-type Ca2 ...... n mouse pancreatic beta-cells.
@nl
prefLabel
Palmitate increases L-type Ca2 ...... n mouse pancreatic beta-cells.
@en
Palmitate increases L-type Ca2 ...... n mouse pancreatic beta-cells.
@nl
P2860
P1476
Palmitate increases L-type Ca2 ...... n mouse pancreatic beta-cells.
@en
P2093
Cecilia Holm
Charlotta S Olofsson
P2860
P304
P356
10.1113/JPHYSIOL.2004.066258
P407
P577
2004-04-16T00:00:00Z