Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules. - Wikidata - wikimedia - TriplyDB

Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

http://www.wikidata.org/entity/Q42117856

about

Distinct initial SNARE configurations underlying the diversity of exocytosis Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in β-cells Subplasmalemmal Ca(2+) measurements in mouse pancreatic beta cells support the existence of an amplifying effect of glucose on insulin secretion Stress-induced dissociations between intracellular calcium signaling and insulin secretion in pancreatic islets The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells.Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature.Lipotoxicity disrupts incretin-regulated human β cell connectivity Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles.Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1.Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration The isolated pancreatic islet as a micro-organ and its transplantation to cure diabetes: celebrating the legacy of Paul Lacy.Protection of Human Pancreatic Islets from Lipotoxicity by Modulation of the Translocon Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic β-cells Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity Ca2+ influx through L-type Ca2+ channels and Ca2+-induced Ca2+ release regulate cAMP accumulation and Epac1-dependent ERK 1/2 activation in INS-1 cells.Differential development of glucose intolerance and pancreatic islet adaptation in multiple diet induced obesity models.Elevated Basal Insulin Secretion in Type 2 Diabetes Caused by Reduced Plasma Membrane Cholesterol.Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.Uncoupling of Cav1.2 from Ca(2+)-induced Ca(2+) release and SK channel regulation in pancreatic β-cells.Regulation of calcium in pancreatic α- and β-cells in health and disease.Diabetes mellitus and the β cell: the last ten years.Cholesterol-enriched membrane rafts and insulin secretion.Insulin secretion from beta cells within intact islets: location matters.On depolarization-evoked exocytosis as a function of calcium entry: possibilities and pitfalls.Beta cell response to nutrient overload involves phospholipid remodelling and lipid peroxidation.Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells.Effects of lipotoxicity on a novel insulin-secreting human pancreatic β-cell line, 1.1B4.Beta cell dysfunction and insulin resistance Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets.Exocytosis from pancreatic β-cells: mathematical modelling of the exit of low-molecular-weight granule content.SHIP2 on pI3K/Akt pathway in palmitic acid stimulated islet β cell.A biophysical model of electrical activity in human β-cells.SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Vascular endothelial growth factor-B: Impact on physiology and pathology.Metabolic activity induces membrane phase separation in endoplasmic reticulum.

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P2860

Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

http://www.wikidata.org/entity/Q42117856

description

2009 nî lūn-bûn

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2009年の論文

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name

Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca

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type

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Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca

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Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca

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J.CMET.2009.09.011

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Cell Metabolism

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Frances M Ashcroft

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Michael B Hoppa

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Paul Johnson

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Quan Zhang

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Reshma Ramracheya

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Stefan Amisten

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P2860

Assessment of erythrocyte phospholipid fatty acid composition as a biomarker for dietary MUFA, PUFA or saturated fatty acid intake in a controlled cross-over intervention trial

A simple method for the isolation and purification of total lipides from animal tissues

Signals and pools underlying biphasic insulin secretion.

Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells

Mechanisms linking obesity to insulin resistance and type 2 diabetes

Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis.

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus.

Systematic screening for palmitoyl transferase activity of the DHHC protein family in mammalian cells.

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

Interaction between free fatty acids and glucose metabolism.

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40038540

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