Guide RNA functional modules direct Cas9 activity and orthogonality.
about
Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogationDiversity of CRISPR-Cas immune systems and molecular machinesEnabling functional genomics with genome engineeringAdvances in CRISPR-Cas9 genome engineering: lessons learned from RNA interferenceBiogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunitySTRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognitionMutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response.Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas SystemsAn updated evolutionary classification of CRISPR-Cas systems.Harnessing the Potential of Human Pluripotent Stem Cells and Gene Editing for the Treatment of Retinal Degeneration.Genetic and epigenetic control of gene expression by CRISPR-Cas systems.In vivo genome editing using Staphylococcus aureus Cas9Rational design of a split-Cas9 enzyme complexMultiplexable, locus-specific targeting of long RNAs with CRISPR-Display.Structure and Engineering of Francisella novicida Cas9.Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switchApplications of CRISPR technologies in research and beyond.Occurrence and Diversity of CRISPR-Cas Systems in the Genus BifidobacteriumCRISPR-based screening of genomic island excision events in bacteria.Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavageDifferential Distribution of Type II CRISPR-Cas Systems in Agricultural and Nonagricultural Campylobacter coli and Campylobacter jejuni Isolates Correlates with Lack of Shared EnvironmentsDiversity and evolution of class 2 CRISPR-Cas systems.Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 EnzymesCrystal Structure of Staphylococcus aureus Cas9Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human GenomeKinetics of the CRISPR-Cas9 effector complex assembly and the role of 3'-terminal segment of guide RNA.Conformational control of DNA target cleavage by CRISPR-Cas9.A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular ResearchEditing the epigenome: technologies for programmable transcription and epigenetic modulation.Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs.Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease.DNA and RNA interference mechanisms by CRISPR-Cas surveillance complexes.CRISPR-Based Technologies and the Future of Food Science.Few basepairing-independent motifs in the apical half of the avian HBV ε RNA stem-loop determine site-specific initiation of protein-priming.Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity.Guide RNA engineering for versatile Cas9 functionalityDeciphering, Communicating, and Engineering the CRISPR PAM.Genome editing approaches: manipulating of lovastatin and taxol synthesis of filamentous fungi by CRISPR/Cas9 system.A decade of discovery: CRISPR functions and applications.
P2860
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P2860
Guide RNA functional modules direct Cas9 activity and orthogonality.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh-hant
name
Guide RNA functional modules direct Cas9 activity and orthogonality.
@en
Guide RNA functional modules direct Cas9 activity and orthogonality.
@nl
type
label
Guide RNA functional modules direct Cas9 activity and orthogonality.
@en
Guide RNA functional modules direct Cas9 activity and orthogonality.
@nl
prefLabel
Guide RNA functional modules direct Cas9 activity and orthogonality.
@en
Guide RNA functional modules direct Cas9 activity and orthogonality.
@nl
P2093
P50
P1433
P1476
Guide RNA functional modules direct Cas9 activity and orthogonality.
@en
P2093
Ahmed A Gomaa
Andrew P May
Christopher H Nye
Euan M Slorach
Kurt Selle
Paul D Donohoue
Rachel E Haurwitz
P304
P356
10.1016/J.MOLCEL.2014.09.019
P577
2014-10-16T00:00:00Z