Conformational control of DNA target cleavage by CRISPR-Cas9.
about
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavageA Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene RegulationStructure of a group II intron in complex with its reverse transcriptaseStriking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations.Disabling Cas9 by an anti-CRISPR DNA mimicHigh-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.Structure and Engineering of Francisella novicida Cas9.Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems.Applications of CRISPR technologies in research and beyond.Diversity and evolution of class 2 CRISPR-Cas systems.High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding.Nucleosome breathing and remodeling constrain CRISPR-Cas9 function.CRISPR-Cas9 nuclear dynamics and target recognition in living cells.Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease.Profiling single-guide RNA specificity reveals a mismatch sensitive core sequence.The Discovery, Mechanisms, and Evolutionary Impact of Anti-CRISPRs.CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations.CRISPR-Cas9 Mediated DNA Unwinding Detected Using Site-Directed Spin Labeling.Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9.Salient Features of Endonuclease Platforms for Therapeutic Genome EditingNucleosomes Selectively Inhibit Cas9 Off-target Activity at a Site Located at the Nucleosome Edge.Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem CellsStructural and dynamic views of the CRISPR-Cas system at the single-molecule level.Probing the structural dynamics of the CRISPR-Cas9 RNA-guided DNA-cleavage system by coarse-grained modeling.Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.Next stop for the CRISPR revolution: RNA-guided epigenetic regulators.Transcriptional regulation with CRISPR-Cas9: principles, advances, and applications.Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity.Guide RNA engineering for versatile Cas9 functionalityTen years of iPSC: clinical potential and advances in vitro hematopoietic differentiation.Lessons from Enzyme Kinetics Reveal Specificity Principles for RNA-Guided Nucleases in RNA Interference and CRISPR-Based Genome Editing.CRISPR/Cas9: at the cutting edge of hepatology.A decade of discovery: CRISPR functions and applications.Conformational regulation of CRISPR-associated nucleases.Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.A Broad-Spectrum Inhibitor of CRISPR-Cas9.Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9.Biochemical characterization of a thermostable HNH endonuclease from deep-sea thermophilic bacteriophage GVE2.Engineering of CRISPR/Cas9-mediated potyvirus resistance in transgene-free Arabidopsis plants.A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9
P2860
Q27703932-022375AF-98CB-457E-8AD6-F5BB86992C88Q28552981-FAF432D8-6455-4788-A602-15684F510EFFQ30387554-3415F784-E67A-438D-8060-DCD2C28C8B72Q30826748-1E72699B-1842-4BDE-A8C1-51F0BD92556FQ33898855-8618F47F-4EA8-4C1B-B98F-B7DAE0C82DCCQ34507554-72187070-74F7-4AF0-973A-21691CFA7927Q34514052-7911C3B2-715E-4CC9-8776-3D4A958EC835Q34536517-FBF55B24-1F5A-45E9-869D-4AFC81211604Q34539796-17AB38D6-C9D2-42C2-8D49-6EFF28D3A092Q36256836-104AEFCC-2435-459F-B28B-D75B58D8FB5BQ36369721-75BAAC15-87C1-48B2-858D-765862A85D08Q36936033-E20D8374-D720-4E8C-92B4-D356595786F5Q37216431-CD3585FC-ED5B-40B7-8FB9-2AC0E977FC41Q37396156-EBA1D31F-967E-45C3-80E3-6255EDF6E762Q37591346-C3BCED7D-30F7-4464-914F-A7CBB12127DCQ38651010-7AE6E80B-78D7-436B-9741-A1F266F5EEE1Q38666403-E5E1C0F8-4A2F-4D19-9442-842390C99205Q38691551-AF19E77A-5269-4F2A-9C2F-E9E99D55BB28Q38695021-6A5E589D-3757-45EE-B638-0C2FE65958D7Q38706622-637BE892-FC94-4EE8-B7B6-3A9F712D9779Q38739783-835D27B3-87C7-4F9D-B24E-BE33E0FDD71EQ38751441-4D07316C-CA71-45A4-92DB-B0E083D2DC18Q38753545-0F571B1E-0C75-4F8E-BD6A-CEF54086CE81Q38784917-0C1A9C1F-47FB-40D2-B7F7-50FBCAB67317Q38810667-2D6CBE12-8A08-4028-9463-E08F53E08A88Q38850026-551BF3BF-FC31-4EE5-BB87-17165DCDC93AQ38877182-632DE871-3C15-462C-A381-64CC0738EE13Q38919610-28C5FFDF-3436-4C86-80C6-EB09A8724914Q38979117-DFE30AEF-4441-4A57-9E88-1B9B2CD711C1Q39063423-2C362C3E-78DC-4C60-9980-1AACFECC651CQ39105063-5B4E1628-180C-43B3-A455-FE474E6B0838Q39294371-5F14956F-0C3F-4284-9124-A0EA19B50F75Q39350951-469D08BA-9392-417D-BEC6-F5A109CA0755Q39395687-C04B4443-E925-4FE0-86EA-EF9BD7273DE7Q39909317-02E3312C-9210-4630-8F63-C2BF5AEF67D2Q40068953-6E6CE499-47DB-46C9-82A2-9B457889CD79Q40164344-9EE8617E-FEE9-4DE0-963B-63EC0D8C102BQ40774728-96138816-B06B-4391-8ED0-B9D103C39595Q40786745-19585126-DBAC-45C7-AF9B-A222E92A7B81Q41294785-34DA504B-CA6F-4043-B058-1A8EE4B4732B
P2860
Conformational control of DNA target cleavage by CRISPR-Cas9.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Conformational control of DNA target cleavage by CRISPR-Cas9.
@en
type
label
Conformational control of DNA target cleavage by CRISPR-Cas9.
@en
prefLabel
Conformational control of DNA target cleavage by CRISPR-Cas9.
@en
P2860
P356
P1433
P1476
Conformational control of DNA target cleavage by CRISPR-Cas9.
@en
P2093
Benjamin LaFrance
Samuel H Sternberg
P2860
P2888
P304
P356
10.1038/NATURE15544
P407
P577
2015-10-28T00:00:00Z
P6179
1047311922