Protein phosphatase 1 associates with the integrin alphaIIb subunit and regulates signaling.
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Structure and function of the platelet integrin alphaIIbbeta3Structural Basis for the Activation of Platelet Integrin αIIbβ3 by Calcium- and Integrin-Binding Protein 1Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling.The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function.Pro32Pro33 mutations in the integrin β3 PSI domain result in αIIbβ3 priming and enhanced adhesion: reversal of the hypercoagulability phenotype by the Src inhibitor SKI-606.G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets.Differential dephosphorylation of the protein kinase C-zeta (PKCζ) in an integrin αIIbβ3-dependent manner in plateletsDissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1)The crystal structure of calcium- and integrin-binding protein 1: insights into redox regulated functionsIntegrin antagonists as therapeutics for inflammatory diseases.Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in plateletsPlatelet signaling-a primer.Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling.Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.A novel functional role for the highly conserved alpha-subunit KVGFFKR motif distinct from integrin alphaIIbbeta3 activation processes.Mechanism of activation and functional role of protein kinase Ceta in human platelets.Calcium- and magnesium-dependent interactions between calcium- and integrin-binding protein and the integrin alphaIIb cytoplasmic domain.Increased activity of phosphatase PP2A in the presence of the PlA2 polymorphism of alphaIIbbeta3.The Pro33 isoform of integrin beta3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases.A role for PKCtheta in outside-in alpha(IIb)beta3 signaling.
P2860
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P2860
Protein phosphatase 1 associates with the integrin alphaIIb subunit and regulates signaling.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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name
Protein phosphatase 1 associat ...... bunit and regulates signaling.
@en
Protein phosphatase 1 associat ...... bunit and regulates signaling.
@nl
type
label
Protein phosphatase 1 associat ...... bunit and regulates signaling.
@en
Protein phosphatase 1 associat ...... bunit and regulates signaling.
@nl
prefLabel
Protein phosphatase 1 associat ...... bunit and regulates signaling.
@en
Protein phosphatase 1 associat ...... bunit and regulates signaling.
@nl
P2093
P2860
P356
P1476
Protein phosphatase 1 associat ...... bunit and regulates signaling.
@en
P2093
K Vinod Vijayan
Paul F Bray
Tong-Tong Li
P2860
P304
33039-33042
P356
10.1074/JBC.C400239200
P407
P577
2004-06-17T00:00:00Z