Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A. - Wikidata - wikimedia - TriplyDB

Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.

Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.

http://www.wikidata.org/entity/Q40663995

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Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins.Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells A triad of lys12, lys41, arg78 spatial domain, a novel identified heparin binding site on tat protein, facilitates tat-driven cell adhesion.Myosin-X provides a motor-based link between integrins and the cytoskeleton.Analysis of conserved residues in the betapat-3 cytoplasmic tail reveals important functions of integrin in multiple tissues.Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network.Integrins: roles in cancer development and as treatment targets.Integrin β1 mediates vaccinia virus entry through activation of PI3K/Akt signaling.The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoA A Rac switch regulates random versus directionally persistent cell migration.Loss of miR-200b promotes invasion via activating the Kindlin-2/integrin β1/AKT pathway in esophageal squamous cell carcinoma: An E-cadherin-independent mechanism Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response.beta1 integrin cytoplasmic domain residues selectively modulate fibronectin matrix assembly and cell spreading through talin and Akt-1.Integrins are required for the differentiation of visceral endoderm Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors.Roles of matrix metalloproteinases and their targets in epileptogenesis and seizures The role of ERK5 in endothelial cell function.The impact of quercetin on wound healing relates to changes in αV and β1 integrin expression.Cell proliferation in in vivo-like three-dimensional cell culture is regulated by sequestration of ERK1/2 to lipid rafts.Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling.Structural organization of the cytoskeleton in SV40 human corneal epithelial cells cultured on nano- and microscale grooves A novel Epac-Rap-PP2A signaling module controls cAMP-dependent Akt regulation Polymerized collagen inhibits fibroblast proliferation via a mechanism involving the formation of a beta1 integrin-protein phosphatase 2A-tuberous sclerosis complex 2 complex that suppresses S6K1 activity.beta1-Integrins induce phosphorylation of Akt on serine 473 independently of focal adhesion kinase and Src family kinases.PTEN regulates fibroblast elimination during collagen matrix contraction.Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells.Passive mechanical forces upregulate the fast myosin heavy chain IId/x via integrin and p38 MAP kinase activation in a primary muscle cell culture.Response of descending vasa recta to luminal pressure.Protein phosphatase 1 associates with the integrin alphaIIb subunit and regulates signaling.Minocycline reduces oxygen-glucose deprivation-induced PC12 cell cytotoxicity via matrix metalloproteinase-9, integrin β1 and phosphorylated Akt modulation.

P2860

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P2860

Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.

http://www.wikidata.org/entity/Q40663995

description

2003 nî lūn-bûn

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

2003年论文

@zh

2003年论文

@zh-cn

name

Specific beta1 integrin site s ...... ion of protein phosphatase 2A.

@en

type

label

Specific beta1 integrin site s ...... ion of protein phosphatase 2A.

@en

prefLabel

Specific beta1 integrin site s ...... ion of protein phosphatase 2A.

@en

P1433

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P698

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P356

P1433

Journal of Biological Chemistry

P1476

Specific beta1 integrin site s ...... ion of protein phosphatase 2A.

@en

P2093

Benoit Poulin

http://www.w3.org/2001/XMLSchema#string

Cornelia Hahn

http://www.w3.org/2001/XMLSchema#string

Edna Cukierman

http://www.w3.org/2001/XMLSchema#string

Katherine Clark

http://www.w3.org/2001/XMLSchema#string

Kazue Matsumoto

http://www.w3.org/2001/XMLSchema#string

P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

P304

18671-18681

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scholarly article

P356

10.1074/JBC.M300879200

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P433

20

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P478

278

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P577

2003-03-11T00:00:00Z

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P698

12637511

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