Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway.
about
A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28The Novel PKCθ from Benchtop to ClinicPKCtheta is necessary for efficient activation of NFkappaB, NFAT, and AP-1 during positive selection of thymocytes.ERK positive feedback regulates a widespread network of tyrosine phosphorylation sites across canonical T cell signaling and actin cytoskeletal proteins in Jurkat T cells.IFNα signaling through PKC-θ is essential for antitumor NK cell functionTEC-family kinases: regulators of T-helper-cell differentiation.A critical role for protein kinase C-theta-mediated T cell survival in cardiac allograft rejection.Protein kinase C theta (PKCtheta): a key player in T cell life and deathNK cell-activating receptors require PKC-theta for sustained signaling, transcriptional activation, and IFN-gamma secretion.The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunityDifferential requirement of PKC-theta in the development and function of natural regulatory T cells.PRKCQ promotes oncogenic growth and anoikis resistance of a subset of triple-negative breast cancer cells.A new approach for quantitative phosphoproteomic dissection of signaling pathways applied to T cell receptor activation.The yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression.PKC-θ is a drug target for prevention of T cell-mediated autoimmunity and allograft rejection.The role of Tec family kinases in the regulation of T-helper-cell differentiation.Rapid induction and activation of Tec tyrosine kinase in liver regeneration.PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription.Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway.Protein kinase C-θ promotes Th17 differentiation via upregulation of Stat3.Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor ImmunityHuman immunodeficiency virus reactivation by phorbol esters or T-cell receptor ligation requires both PKCalpha and PKCtheta.The role of ERK5 in T-cell signalling.
P2860
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P2860
Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Positive feedback regulation of PLCgamma1/Ca
@nl
Positive feedback regulation o ...... Tec kinase-dependent pathway.
@en
type
label
Positive feedback regulation of PLCgamma1/Ca
@nl
Positive feedback regulation o ...... Tec kinase-dependent pathway.
@en
prefLabel
Positive feedback regulation of PLCgamma1/Ca
@nl
Positive feedback regulation o ...... Tec kinase-dependent pathway.
@en
P2093
P356
P1476
Positive feedback regulation o ...... a Tec kinase-dependent pathway
@en
P2093
Amnon Altman
Robert A Hipskind
Sandra Kaminski
Valere Busuttil
Yuri Tadevosyan
P304
P356
10.1002/EJI.200324625
P407
P577
2004-07-01T00:00:00Z