Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS).
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Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase.Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray CrystallographyCyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor DesignCrystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain CommunicationStructural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMPPotent Neutralization of Vaccinia Virus by Divergent Murine Antibodies Targeting a Common Site of Vulnerability in L1 ProteinTheoretical Insights Reveal Novel Motions in Csk's SH3 Domain That Control Kinase Activation.Distal loop flexibility of a regulatory domain modulates dynamics and activity of C-terminal SRC kinase (csk)Changes in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS.Signaling through dynamic linkers as revealed by PKAH7N9 influenza virus neutralizing antibodies that possess few somatic mutationsDiscovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.Exploring the interaction between the protein kinase A catalytic subunit and caveolin-1 scaffolding domain with shotgun scanning, oligomer complementation, NMR, and dockingDetection of lipid-induced structural changes of the Marburg virus matrix protein VP40 using hydrogen/deuterium exchange-mass spectrometryEbola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusionMechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS).Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.Isoform-specific antagonists of exchange proteins directly activated by cAMPThe amino terminus of cGMP-dependent protein kinase Iβ increases the dynamics of the protein's cGMP-binding pocketscAMP activation of PKA defines an ancient signaling mechanism.A large family with Carney complex caused by the S147G PRKAR1A mutation shows a unique spectrum of disease including adrenocortical cancerCyclic AMP-induced conformational changes in mycobacterial protein acetyltransferases.R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry.Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.Unraveling the molecular basis of micronodular adrenal hyperplasia.Mass spectrometric analysis of protein-ligand interactions.Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometryLocation of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry.Structural insights into glucan phosphatase dynamics using amide hydrogen-deuterium exchange mass spectrometry.Sensing domain dynamics in protein kinase A-I{alpha} complexes by solution X-ray scattering.In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay.Analyses of Calcium-Independent Phospholipase A2beta (iPLA2β) in Biological Systems.Determination of Equine Cytochrome c Backbone Amide Hydrogen/Deuterium Exchange Rates by Mass Spectrometry Using a Wider Time Window and Isotope Envelope.Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry.Lipoprotein-associated phospholipase A(2) interacts with phospholipid vesicles via a surface-disposed hydrophobic α-helix.Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry.Crystal Structure of the Oligomeric Form of Lassa Virus Matrix Protein Z.PAS domain allostery and light-induced conformational changes in photoactive yellow protein upon I2 intermediate formation, probed with enhanced hydrogen/deuterium exchange mass spectrometry.Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry.Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics.
P2860
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P2860
Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS).
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Mapping intersubunit interacti ...... ange mass spectrometry (DXMS).
@en
Mapping intersubunit interactions of the regulatory subunit
@nl
type
label
Mapping intersubunit interacti ...... ange mass spectrometry (DXMS).
@en
Mapping intersubunit interactions of the regulatory subunit
@nl
prefLabel
Mapping intersubunit interacti ...... ange mass spectrometry (DXMS).
@en
Mapping intersubunit interactions of the regulatory subunit
@nl
P2093
P1476
Mapping intersubunit interacti ...... ange mass spectrometry (DXMS).
@en
P2093
Celina Juliano
David D Stranz
Ganesh S Anand
Jack S Kim
Susan S Taylor
Virgil L Woods
Yoshimoto Hamuro
P304
P356
10.1016/J.JMB.2004.05.042
P407
P577
2004-07-01T00:00:00Z