Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy.
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Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malariaCrystal Structures of the Histo-Aspartic Protease (HAP) from Plasmodium falciparumBestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidasesRoles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparumPurification of components of the translation elongation factor complex of Plasmodium falciparum by tandem affinity purificationFunctional analysis of the exported type IV HSP40 protein PfGECO in Plasmodium falciparum gametocytesA role for falcilysin in transit peptide degradation in the Plasmodium falciparum apicoplastCharacterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug developmentProteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivityPlasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria.Evaluation of aminohydantoins as a novel class of antimalarial agents.Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design.Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probesPlasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systemsSynergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro.Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.Aspartyl Proteinases of Eukaryotic Microbial Pathogens: From Eating to HeatingNew approaches for dissecting protease functions to improve probe development and drug discoveryStronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum.Malarial proteases and host cell egress: an 'emerging' cascade.New roles for perforins and proteases in apicomplexan egressPlasmodium falciparum: new molecular targets with potential for antimalarial drug development.Threonine peptidases as drug targets against malaria.Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors.Flap flexibility amongst plasmepsins I, II, III, IV, and V: Sequence, structural, and molecular dynamics analyses.Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance.Synergy of the antiretroviral protease inhibitor indinavir and chloroquine against malaria parasites in vitro and in vivo.Novel diaryl ureas with efficacy in a mouse model of malaria.X-ray structure of plasmepsin II complexed with a potent achiral inhibitor.Calculation of binding free energies of inhibitors to plasmepsin II.Sequence, Structural Analysis and Metrics to Define the Unique Dynamic Features of the Flap Regions Among Aspartic Proteases.Inactivation of Plasmepsin 2 and 3 sensitizes Plasmodium falciparum to the antimalarial drug piperaquine.Deciphering the targets of retroviral protease inhibitors in Plasmodium bergheiAllosteric Site Inhibitor Disrupting Auto-Processing of Malarial Cysteine Proteases
P2860
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P2860
Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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name
Genetic disruption of the Plas ...... s their functional redundancy.
@en
Genetic disruption of the Plas ...... s their functional redundancy.
@nl
type
label
Genetic disruption of the Plas ...... s their functional redundancy.
@en
Genetic disruption of the Plas ...... s their functional redundancy.
@nl
prefLabel
Genetic disruption of the Plas ...... s their functional redundancy.
@en
Genetic disruption of the Plas ...... s their functional redundancy.
@nl
P2093
P2860
P356
P1476
Genetic disruption of the Plas ...... s their functional redundancy.
@en
P2093
A Levi Omara-Opyene
Carlos R Sulsona
Charles A Yowell
Hisashi Fujioka
J Alfredo Bonilla
John B Dame
Pedro A Moura
P2860
P304
54088-54096
P356
10.1074/JBC.M409605200
P407
P577
2004-10-18T00:00:00Z