Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells.
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GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human diseaseType 5 phosphodiesterase expression is a critical determinant of the endothelial cell angiogenic phenotype.A dose-ranging study of the pharmacokinetics and pharmacodynamics of the selective apoptotic antineoplastic drug (SAAND), OSI-461, in patients with advanced cancer, in the fasted and fed stateSulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase GInhibition of phosphodiestrase 9 induces cGMP accumulation and apoptosis in human breast cancer cell lines, MCF-7 and MDA-MB-468.Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction.Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection.Regulation of OSU-03012 toxicity by ER stress proteins and ER stress-inducing drugs.cGMP-dependent protein kinase Iβ interacts with p44/WDR77 to regulate androgen receptor-driven gene expression.PDE5 inhibitors as therapeutics for heart disease, diabetes and cancerPhosphodiesterase sequence variants may predispose to prostate cancer.Identification of murine phosphodiesterase 5A isoforms and their functional characterization in HL-1 cardiac cell line.Sildenafil inhibits the growth of human colorectal cancer in vitro and in vivoThe cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinomaPhosphodiesterase function and endocrine cells: links to human disease and roles in tumor development and treatmentNovel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases.Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer TherapiesNexavar/Stivarga and viagra interact to kill tumor cells.GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases.β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKGProtein kinase G as a therapeutic target for the treatment of metastatic colorectal cancer.Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell linesSynthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.Targeting cancer with phosphodiesterase inhibitors.Clinical and molecular genetics of the phosphodiesterases (PDEs).The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatmentcGMP-dependent protein kinases as potential targets for colon cancer prevention and treatment.New NSAID targets and derivatives for colorectal cancer chemoprevention.Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter.Inhibitive effects of anti-oxidative vitamins on mannitol-induced apoptosis of vascular endothelial cells.Role of rare germline copy number variation in melanoma-prone patients.Momordica charantia: a popular health-promoting vegetable with multifunctionality.Potential therapeutic applications of phosphodiesterase inhibition in prostate cancer.KMUP-1 inhibits H441 lung epithelial cell growth, migration and proinflammation via increased NO/CGMP and inhibited RHO kinase/VEGF signaling pathways.Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1.t(4;8)(q27;q24) in Hodgkin lymphoma cells targets phosphodiesterase PDE5A and homeobox gene ZHX2.Cyclic 3',5'-guanosine monophosphate-dependent protein kinase inhibits colon cancer cell adaptation to hypoxia.PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4.Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.
P2860
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P2860
Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Suppression of cyclic GMP-spec ...... inhibits growth in HT29 cells.
@en
Suppression of cyclic GMP-spec ...... inhibits growth in HT29 cells.
@nl
type
label
Suppression of cyclic GMP-spec ...... inhibits growth in HT29 cells.
@en
Suppression of cyclic GMP-spec ...... inhibits growth in HT29 cells.
@nl
prefLabel
Suppression of cyclic GMP-spec ...... inhibits growth in HT29 cells.
@en
Suppression of cyclic GMP-spec ...... inhibits growth in HT29 cells.
@nl
P2093
P356
P1476
Suppression of cyclic GMP-spec ...... inhibits growth in HT29 cells.
@en
P2093
Lakshmi Vemavarapu
Samuel J Strada
W Joseph Thompson
P304
P356
10.1002/JCB.20286
P577
2005-02-01T00:00:00Z