Steady-state kinetics and inhibitory action of antitubercular phenothiazines on mycobacterium tuberculosis type-II NADH-menaquinone oxidoreductase (NDH-2).
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Mycobacterium tuberculosis: success through dormancyThe structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substratesStructure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generationType-II NADH:quinone oxidoreductase from Staphylococcus aureus has two distinct binding sites and is rate limited by quinone reductionA Mycobacterium tuberculosis sigma factor network responds to cell-envelope damage by the promising anti-mycobacterial thioridazineActivity of trifluoperazine against replicating, non-replicating and drug resistant M. tuberculosisThe Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domainIdentification of new drug targets and resistance mechanisms in Mycobacterium tuberculosisMycobacterium tuberculosis type II NADH-menaquinone oxidoreductase catalyzes electron transfer through a two-site ping-pong mechanism and has two quinone-binding sitesPolymyxin B identified as an inhibitor of alternative NADH dehydrogenase and malate: quinone oxidoreductase from the Gram-positive bacterium Mycobacterium smegmatis.Characterization of the type 2 NADH:menaquinone oxidoreductases from Staphylococcus aureus and the bactericidal action of phenothiazinesReduced emergence of isoniazid resistance with concurrent use of thioridazine against acute murine tuberculosis.Energetics of Respiration and Oxidative Phosphorylation in Mycobacteria.Reaction mechanism of single subunit NADH-ubiquinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae: evidence for a ternary complex mechanism.Reduction of clofazimine by mycobacterial type 2 NADH:quinone oxidoreductase: a pathway for the generation of bactericidal levels of reactive oxygen species.Targeting bacterial membrane function: an underexploited mechanism for treating persistent infectionsAntitubercular pharmacodynamics of phenothiazinesEnhanced killing of intracellular multidrug-resistant Mycobacterium tuberculosis by compounds that affect the activity of efflux pumps.Purification of two putative type II NADH dehydrogenases with different substrate specificities from alkaliphilic Bacillus pseudofirmus OF4The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosisPerturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis.Involvement of NADH:acceptor oxidoreductase and butyryl coenzyme A dehydrogenase in reversed electron transport during syntrophic butyrate oxidation by Syntrophomonas wolfei.A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activityEnergy metabolism and drug efflux in Mycobacterium tuberculosisProtein targets for structure-based anti-Mycobacterium tuberculosis drug discovery.Antituberculosis drug research: a critical overview.Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions.Understanding the pathophysiology of the human TB lung granuloma using in vitro granuloma models.Thioridazine: A Non-Antibiotic Drug Highly Effective, in Combination with First Line Anti-Tuberculosis Drugs, against Any Form of Antibiotic Resistance of Mycobacterium tuberculosis Due to Its Multi-Mechanisms of Action.The mechanism of catalysis by type-II NADH:quinone oxidoreductases.Type-II NADH Dehydrogenase (NDH-2): a promising therapeutic target for antitubercular and antibacterial drug discovery.Expression, purification, crystallization and preliminary X-ray diffraction analysis of a type II NADH:quinone oxidoreductase from the human pathogen Staphylococcus aureus.Quinolinyl Pyrimidines: Potent Inhibitors of NDH-2 as a Novel Class of Anti-TB Agents.Anaerobic Mycobacterium tuberculosis cell death stems from intracellular acidification mitigated by the DosR regulon.Development of new antituberculous agents based on new drug targets and structure-activity relationship.Antibiotic Bactericidal Activity Is Countered by Maintaining pH Homeostasis in Mycobacterium smegmatis.Novel non-neuroleptic phenothiazines inhibit Mycobacterium tuberculosis replication.Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4(1H)quinolone, a high-affinity inhibitor of alternative (type II) NADH dehydrogenasesNitrate enhances the survival of Mycobacterium tuberculosis during inhibition of respiration.Roles of bound quinone in the single subunit NADH-quinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae.
P2860
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P2860
Steady-state kinetics and inhibitory action of antitubercular phenothiazines on mycobacterium tuberculosis type-II NADH-menaquinone oxidoreductase (NDH-2).
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Steady-state kinetics and inhi ...... uinone oxidoreductase (NDH-2).
@en
Steady-state kinetics and inhi ...... ADH-menaquinone oxidoreductase
@nl
type
label
Steady-state kinetics and inhi ...... uinone oxidoreductase (NDH-2).
@en
Steady-state kinetics and inhi ...... ADH-menaquinone oxidoreductase
@nl
prefLabel
Steady-state kinetics and inhi ...... uinone oxidoreductase (NDH-2).
@en
Steady-state kinetics and inhi ...... ADH-menaquinone oxidoreductase
@nl
P2093
P2860
P356
P1476
Steady-state kinetics and inhi ...... uinone oxidoreductase (NDH-2).
@en
P2093
Edward Weinstein
Harvey Rubin
Jiah-Shin Teh
Lin-Sheng Li
Takahiro Yano
P2860
P304
11456-11463
P356
10.1074/JBC.M508844200
P407
P577
2006-02-09T00:00:00Z