Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease.
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Targeting heat shock proteins to modulate α-synuclein toxicityMolecular chaperones and co-chaperones in Parkinson diseaseThe HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathyChronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell lossHeat shock protein responses to aging and proteotoxicity in the olfactory bulb.Heat shock proteins in neurodegenerative disorders and agingHuman gene therapy and imaging in neurological diseases.Role of the ubiquitin proteasome system in Parkinson's disease.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesMolecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathiesIncreased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice.Heat shock protein 70 (hsp70) as an emerging drug target.Hsp70 and its molecular role in nervous system diseasesRNA metabolism in the pathogenesis of Parkinson׳s diseaseVersatile somatic gene transfer for modeling neurodegenerative diseases.Are heat shock proteins therapeutic target for Parkinson's disease?Drosophila models of neurodegenerative diseases.Heat shock protein defenses in the neocortex and allocortex of the telencephalon.Serum- and Glucocorticoid-Inducible Kinase 1 Confers Protection in Cell-Based and in In Vivo Neurotoxin Models via the c-Jun N-Terminal Kinase Signaling Pathway.Molecular chaperones in Parkinson's disease--present and futureNeuronal cell death in neurodegenerative diseases: recurring themes around protein handling.Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans.Immunology of neurological gene therapy: how T cells modulate viral vector-mediated therapeutic transgene expression through immunological synapsesHeat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival.Engineering therapeutic protein disaggregases.Gene therapy for misfolding protein diseases of the central nervous system.Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps.Recent advances in using Drosophila to model neurodegenerative diseases.Molecular chaperones as rational drug targets for Parkinson's disease therapeutics.Protective role of heat shock proteins in Parkinson's disease.Molecular chaperones and associated cellular clearance mechanisms against toxic protein conformers in Parkinson's disease.Drug targets from genetics: α-synuclein.Molecular chaperones, α-synuclein, and neurodegeneration.Silencing of Hsp70 intensifies 6-OHDA-induced apoptosis and Hsp90 upregulation in PC12 cells.Neural Stem Cells Derived From Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinsons Disease.Investigational α-synuclein aggregation inhibitors: hope for Parkinson's disease.Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease.Neuroprotective therapy in Parkinson's disease: current status and new directions from experimental and genetic clues.Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90.Chaperone-Based Therapies for Disease Modification in Parkinson's Disease.
P2860
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P2860
Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Hsp70 gene transfer by adeno-a ...... se model of Parkinson disease.
@en
Hsp70 gene transfer by adeno-a ...... se model of Parkinson disease.
@nl
type
label
Hsp70 gene transfer by adeno-a ...... se model of Parkinson disease.
@en
Hsp70 gene transfer by adeno-a ...... se model of Parkinson disease.
@nl
prefLabel
Hsp70 gene transfer by adeno-a ...... se model of Parkinson disease.
@en
Hsp70 gene transfer by adeno-a ...... se model of Parkinson disease.
@nl
P2093
P1433
P1476
Hsp70 gene transfer by adeno-a ...... se model of Parkinson disease.
@en
P2093
David P Wolfer
Hansruedi Büeler
Zhizhong Dong
P356
10.1016/J.YMTHE.2004.09.007
P577
2005-01-01T00:00:00Z