Mutant huntingtin affects the rate of transcription of striatum-specific isoforms of phosphodiesterase 10A.
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Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment responseStructural insight into substrate specificity of phosphodiesterase 10Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicityRadiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brainReview: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibitionTransgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats.Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington's DiseaseCyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies.Transcriptional signatures in Huntington's disease.Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent mannerA novel thermoregulatory role for PDE10A in mouse and human adipocytesAdipose tissue dysfunction tracks disease progression in two Huntington's disease mouse modelsIntrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice.Radiosynthesis and Radiotracer Properties of a 7-(2-[18F]Fluoroethoxy)-6-methoxypyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET.Clinical and molecular genetics of the phosphodiesterases (PDEs).Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice.Early and late events induced by polyQ-expanded proteins: identification of a common pathogenic property of polYQ-expanded proteins.Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease.PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model.Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease.Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.Role of Phosphodiesterases in Huntington's Disease.Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry.
P2860
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P2860
Mutant huntingtin affects the rate of transcription of striatum-specific isoforms of phosphodiesterase 10A.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
@zh-hans
2004年学术文章
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name
Mutant huntingtin affects the ...... orms of phosphodiesterase 10A.
@en
Mutant huntingtin affects the ...... orms of phosphodiesterase 10A.
@nl
type
label
Mutant huntingtin affects the ...... orms of phosphodiesterase 10A.
@en
Mutant huntingtin affects the ...... orms of phosphodiesterase 10A.
@nl
prefLabel
Mutant huntingtin affects the ...... orms of phosphodiesterase 10A.
@en
Mutant huntingtin affects the ...... orms of phosphodiesterase 10A.
@nl
P2093
P2860
P1476
Mutant huntingtin affects the ...... orms of phosphodiesterase 10A.
@en
P2093
Andrea L O Hebb
Eileen M Denovan-Wright
Elizabeth A McCaw
Geraldine T Gomez
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P304
P356
10.1111/J.1460-9568.2004.03796.X
P407
P577
2004-12-01T00:00:00Z