Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats.
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PDE4 as a target for cognition enhancementPhosphodiesterases in neurodegenerative disordersThe DISC locus in psychiatric illnessPhosphodiesterases as therapeutic targets for Alzheimer's disease.RACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5The phosphodiesterase-4 (PDE4) inhibitor rolipram decreases ethanol seeking and consumption in alcohol-preferring Fawn-Hooded ratsA novel neurotrophic drug for cognitive enhancement and Alzheimer's diseaseGEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic dosesPDE4 inhibition enhances hippocampal synaptic plasticity in vivo and rescues MK801-induced impairment of long-term potentiation and object recognition memory in an animal model of psychosisPhosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes.Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism.A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia.Alzheimer's disease and age-related memory decline (preclinical)Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress.Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques.The cyclic AMP phenotype of fragile X and autismSelective phosphodiesterase inhibitors: a promising target for cognition enhancement.Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus.The effects of clonidine on discrete-trial delayed spatial alternation in two rat models of memory loss.Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous SystemPhosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling.Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling.Changes in NMDA receptor-induced cyclic nucleotide synthesis regulate the age-dependent increase in PDE4A expression in primary cortical cultures.The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice.The phosphodiesterase-4 inhibitor rolipram attenuates heroin-seeking behavior induced by cues or heroin priming in rats.Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus.Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats.Inhibition of phosphodiesterase-4 reverses the cognitive dysfunction and oxidative stress induced by Aβ25-35 in rats.The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action.Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia.The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats.Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats.Cyclic nucleotide phosphodiesterases: potential therapeutic targets for alcohol use disorder.
P2860
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P2860
Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Effects of the novel PDE4 inhi ...... itory avoidance tests in rats.
@en
Effects of the novel PDE4 inhi ...... itory avoidance tests in rats.
@nl
type
label
Effects of the novel PDE4 inhi ...... itory avoidance tests in rats.
@en
Effects of the novel PDE4 inhi ...... itory avoidance tests in rats.
@nl
prefLabel
Effects of the novel PDE4 inhi ...... itory avoidance tests in rats.
@en
Effects of the novel PDE4 inhi ...... itory avoidance tests in rats.
@nl
P2093
P1433
P1476
Effects of the novel PDE4 inhi ...... itory avoidance tests in rats.
@en
P2093
Alicia M Crissman
Allen T Hopper
Chengjun Deng
Gregory M Rose
Han-Ting Zhang
Michael De Vivo
Neesha U Suvarna
Ying Huang
P2888
P304
P356
10.1007/S00213-004-2085-2
P577
2005-01-26T00:00:00Z
P5875
P6179
1017565085