Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.
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Pharmacological manipulation of cell death: clinical applications in sight?Inhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice culturesCellular interplay between neurons and glia: toward a comprehensive mechanism for excitotoxic neuronal loss in neurodegenerationIslet amyloid in type 2 diabetes, and the toxic oligomer hypothesism-Calpain is required for preimplantation embryonic development in mice.The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degenerationTargeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-OgnaEndonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosisGlutamate receptor activation evokes calpain-mediated degradation of Sp3 and Sp4, the prominent Sp-family transcription factors in neuronsInvolvement of calpains in adult neurogenesis: implications for stroke.Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type miceComprehensive behavioral phenotyping of calpastatin-knockout mice.Calpain activity is essential in skin wound healing and contributes to scar formation.Neuroprotection by sodium ferulate against glutamate-induced apoptosis is mediated by ERK and PI3 kinase pathways.Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.β-hydroxy-β-methylbutyrate (HMB) prevents sepsis-induced diaphragm dysfunction in miceNeuroprotection with delayed calpain inhibition after transient forebrain ischemia.Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L miceOverexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.A functional interplay between 5-lipoxygenase and μ-calpain affects survival and cytokine profile of human Jurkat T lymphocyte exposed to simulated microgravityComprehensive survey of p94/calpain 3 substrates by comparative proteomics--possible regulation of protein synthesis by p94.Cell signaling underlying epileptic behavior.Calpain chronicle--an enzyme family under multidisciplinary characterizationLoss-of-function mutations in CAST cause peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads.Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival.Nicotinic acetylcholine receptor α1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathyGephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death.Proteolytic mechanisms in necrotic cell death and neurodegeneration.Calpastatin overexpression protects axonal transport in an in vivo model of traumatic axonal injury.Involvement of calpain activation in neurodegenerative processes.IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults.Mechanistic role of calpains in postischemic neurodegeneration.Calpastatin prevents NF-κB-mediated hyperactivation of macrophages and attenuates colitis.Calpain-mediated signaling mechanisms in neuronal injury and neurodegenerationPhysiologic and pathophysiologic role of calpain: implications for the occurrence of atrial fibrillation.In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury.The calpain system and cancer.Impact of genetic insights into calpain biology.Structure-function relationships in calpains.
P2860
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P2860
Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Calpain mediates excitotoxic D ...... from calpastatin mutant mice.
@en
Calpain mediates excitotoxic D ...... from calpastatin mutant mice.
@nl
type
label
Calpain mediates excitotoxic D ...... from calpastatin mutant mice.
@en
Calpain mediates excitotoxic D ...... from calpastatin mutant mice.
@nl
prefLabel
Calpain mediates excitotoxic D ...... from calpastatin mutant mice.
@en
Calpain mediates excitotoxic D ...... from calpastatin mutant mice.
@nl
P2093
P356
P1476
Calpain mediates excitotoxic D ...... e from calpastatin mutant mice
@en
P2093
Jiro Takano
Makoto Higuchi
Masanori Tomioka
Masatoshi Maki
Nobuhisa Iwata
Satoshi Tsubuki
Takaomi C Saido
P304
16175-16184
P356
10.1074/JBC.M414552200
P407
P50
P577
2005-02-02T00:00:00Z