Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids.
about
Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expressionEndocrine fibroblast growth factors 15/19 and 21: from feast to famineBile acids: regulation of synthesisBile acid metabolism and signalingBile acids as metabolic regulatorsGenetic insights into the mechanisms of Fgf signalingBile acid signaling in metabolic disease and drug therapyMechanisms for increased expression of cholesterol 7alpha-hydroxylase (Cyp7a1) in lactating ratsBile acid flux is necessary for normal liver regeneration.Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlothoAll-trans retinoic acid regulates hepatic bile acid homeostasisTissue-specific function of farnesoid X receptor in liver and intestineTumor suppressor p53 regulates bile acid homeostasis via small heterodimer partner.Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway.FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of β-Klotho.Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool.Nuclear bile acid receptor FXR as pharmacological target: are we there yet?Hepatocyte FRS2α is essential for the endocrine fibroblast growth factor to limit the amplitude of bile acid production induced by prandial activity.Grape Seed Procyanidins and Cholestyramine Differentially Alter Bile Acid and Cholesterol Homeostatic Gene Expression in Mouse Intestine and Liver.Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules.Cell signaling and nuclear receptors: new opportunities for molecular pharmaceuticals in liver disease.Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation.Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma.c-Fos mediates repression of the apical sodium-dependent bile acid transporter by fibroblast growth factor-19 in miceBile acids activate YAP to promote liver carcinogenesis.Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23.Restoration of enterohepatic bile acid pathways in pregnant mice following short term activation of Fxr by GW4064.PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma.Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation.A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids.Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis.Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice.Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation.Fibroblast Growth Factor 19 and 7α-Hydroxy-4-Cholesten-3-one in the Diagnosis of Patients With Possible Bile Acid Diarrhea.Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease.Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis.Resolving the mechanism of bile acid negative-feedback regulation, a Journal of Lipid Research tradition.Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models.A threshold model for receptor tyrosine kinase signaling specificity and cell fate determination.
P2860
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P2860
Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Independent repression of bile ...... ptor 4 (FGFR4) and bile acids.
@en
Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase
@nl
type
label
Independent repression of bile ...... ptor 4 (FGFR4) and bile acids.
@en
Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase
@nl
prefLabel
Independent repression of bile ...... ptor 4 (FGFR4) and bile acids.
@en
Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase
@nl
P2093
P2860
P356
P1476
Independent repression of bile ...... ptor 4 (FGFR4) and bile acids.
@en
P2093
Chengliu Jin
Chundong Yu
Wallace L McKeehan
Xinqiang Huang
P2860
P304
17707-17714
P356
10.1074/JBC.M411771200
P407
P577
2005-03-04T00:00:00Z