Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment. - Wikidata - wikimedia - TriplyDB

Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.

Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.

http://www.wikidata.org/entity/Q45307207

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Indoleamine 2,3 Dioxygenase as a Potential Therapeutic Target in Huntington's Disease The choreography of neuroinflammation in Huntington's disease Kynurenines in the mammalian brain: when physiology meets pathology Structural basis of kynurenine 3-monooxygenase inhibition The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease Targeted Deletion of Kynurenine 3-Monooxygenase in Mice: A NEW TOOL FOR STUDYING KYNURENINE PATHWAY METABOLISM IN PERIPHERY AND BRAIN Modeling Huntington disease in yeast: perspectives and future directions.Transcription, epigenetics and ameliorative strategies in Huntington's Disease: a genome-wide perspective Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.The role of the immune system in triplet repeat expansion diseases Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder.Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinoma.Polyglutamine (polyQ) disorders: the chromatin connection.Bone marrow transplantation confers modest benefits in mouse models of Huntington's disease.Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation.Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease.Epigenetics and the modulation of neuroinflammation.Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease.β-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington's Disease.Kynurenines with neuroactive and redox properties: relevance to aging and brain diseases.Molecular mechanisms and potential therapeutical targets in Huntington's disease.Involvement of kynurenines in Huntington's disease and stroke-induced brain damage.Contribution of yeast models to neurodegeneration research.An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity Mitochondrion-mediated cell death: dissecting yeast apoptosis for a better understanding of neurodegeneration.The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease.Glial epigenetics in neuroinflammation and neurodegeneration.Microglia and inflammation: conspiracy, controversy or control?The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia.Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins.Exploring the power of yeast to model aging and age-related neurodegenerative disorders.Development of LC/MS/MS, high-throughput enzymatic and cellular assays for the characterization of compounds that inhibit kynurenine monooxygenase (KMO).The emerging field of epigenetics in neurodegeneration and neuroprotection.On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo.Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity.Effects of mitochondrial dysfunction on the immunological properties of microglia Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species.

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P2860

Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.

http://www.wikidata.org/entity/Q45307207

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Histone deacetylase inhibition ...... a mutant huntingtin fragment.

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Histone deacetylase inhibition ...... a mutant huntingtin fragment.

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type

label

Histone deacetylase inhibition ...... a mutant huntingtin fragment.

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Histone deacetylase inhibition ...... a mutant huntingtin fragment.

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Histone deacetylase inhibition ...... a mutant huntingtin fragment.

@en

Histone deacetylase inhibition ...... a mutant huntingtin fragment.

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Journal of Biological Chemistry

P1476

Histone deacetylase inhibition ...... g a mutant huntingtin fragment

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P2093

Christine S Cheah

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Daniel Zwilling

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Flaviano Giorgini

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Jennifer L Wacker

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Li-Chun L Tsai

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Paolo Guidetti

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Paul J Muchowski

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Robert Schwarcz

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Thomas Möller

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Wanda Kwan

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P2860

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.

Genomewide studies of histone deacetylase function in yeast

Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease

Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse

Early kynurenergic impairment in Huntington's disease and in a transgenic animal model

Human microglia convert l-tryptophan into the neurotoxin quinolinic acid

Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

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7390-7400

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10.1074/JBC.M708192200

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12

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283

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P921

microglial inhibitor