about
RIF1 and PAX1IP bind TP53BP1 at DNA DSBsAssociation of Ku heterodimer with ends of DNA double-strand breakAssociation of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsisTP53BP1 recruits DCLRE1C to ATMActivated ATM phosphorylates DCLRE1CDNA-PKcs autophosphorylatesDCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBsPRKDC phosphorylates DCLRE1C at DNA DSBsDCLRE1C (ARTEMIS) processes DNA DSB endsTDP1 and TDP2 process unligatable DSB endsXRCC4:LIG4; NHEJ1 and POLL or POLM bind DNA DSBs in NHEJPOLL or POLM extends aligned DNA DSB ends to fill gapsXRCC4:LIG4 ligates DNA DSB ends during NHEJ
P361
Q50287398-9DC1FBD8-3ED1-4C75-9A87-A72107943B39Q50287399-0299E976-FDA9-4D5C-AB5A-31D1A0F3E372Q50287400-7CF4D688-4C2F-4AE2-A2CB-8612D10222E9Q50287401-0B0E7E56-CFA0-4D06-9CFB-BF183068C4EEQ50287402-349A68F9-F39E-4EE9-AA17-36F97E1E60ECQ50287403-961512E2-48A3-4755-B662-B9ABAACBC186Q50287404-43055271-061E-4DAD-95A9-D7901B36E169Q50287405-B8EA8715-AD04-4C23-AA4F-962B6091CCD0Q50287406-B0E2336E-F2CA-4BD3-8631-DF0FEBD9976FQ50287407-B41680D1-7840-477C-B7D1-FE1A889E64A2Q50287408-0EA36D7B-7E06-4081-9E1C-35200FEA6E6CQ50287409-95FA706F-FCBA-414C-A8FE-91EEDEB901F4Q50287410-608ADE98-D428-4C61-816F-5F23CF5BE5AB
P361
description
An instance of the biological pathway Nonhomologous End-Joining (NHEJ) in Homo sapiens
@en
name
Nonhomologous End-Joining (NHEJ)
@en
type
label
Nonhomologous End-Joining (NHEJ)
@en
prefLabel
Nonhomologous End-Joining (NHEJ)
@en
P2860
P527
P2860
P3937
R-HSA-5693571