Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1 - Wikidata - wikimedia - TriplyDB

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

http://www.wikidata.org/entity/Q24297882

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Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1 Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV Structure- and function-based characterization of a new phosphoglycolate phosphatase from Thermoplasma acidophilum Pathways for repairing and tolerating the spectrum of oxidative DNA lesions Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.Processing of damaged DNA ends for double-strand break repair in mammalian cells TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition Design and synthesis of fluorescent substrates for human tyrosyl-DNA phosphodiesterase I.Numt-mediated double-strand break repair mitigates deletions during primate genome evolution Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.Nonhomologous end joining: a good solution for bad ends Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents.The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Patching and single-strand ligation in nonhomologous DNA end joining despite persistence of a closely opposed 3'-phosphoglycolate-terminated strand break.Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitors Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1).Neurological disorders associated with DNA strand-break processing enzymes.Recognition and repair of chemically heterogeneous structures at DNA ends Variation in base excision repair capacity.Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1.Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis.

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Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

http://www.wikidata.org/entity/Q24297882

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2002 nî lūn-bûn

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2002年の論文

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Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1

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Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1

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Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1

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Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1

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Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1

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Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1

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Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1

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Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1

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Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1

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Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1

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Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1

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Journal of Biological Chemistry

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Conversion of phosphoglycolate ...... yl-DNA phosphodiesterase hTdp1

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Aghdass Rasouli-Nia

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Jeffrey J Pouliot

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Kedar V Inamdar

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Lawrence F Povirk

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Susan P Lees-Miller

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Tong Zhou

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P2860

Molecular characterization of a human DNA kinase

DNA end-joining catalyzed by human cell-free extracts

Characterization of the human and mouse WRN 3'-->5' exonuclease

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.

Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatases

Incision activity of human apurinic endonuclease (Ape) at abasic site analogs in DNA

Repair of oxidative damage to DNA: enzymology and biology

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3029927

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10.1074/JBC.M204688200

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30

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277

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double-strand break repair

Tyrosyl-DNA phosphodiesterase 1